Literature DB >> 6187403

The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart.

N J Birdsall, A S Burgen, E C Hulme, J M Stockton, M J Zigmond.   

Abstract

McN-A-343 behaves as a competitive agonist in binding to muscarinic receptors in the cerebral cortex. In its interaction with myocardial muscarinic receptors it is not competitive but it retains features of agonist binding.

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Year:  1983        PMID： 6187403      PMCID： PMC2044719          DOI： 10.1111/j.1476-5381.1983.tb09388.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  An unusual type of sympathetic ganglionic stimulant.

Authors:  A P ROSZKOWSKI
Journal:  J Pharmacol Exp Ther       Date:  1961-05       Impact factor: 4.030

2.  The regulation of muscarinic cholinergic receptors by guanine nucleotides in cardiac tissue.

Authors:  L B Rosenberger; W R Roeske; H I Yamamura
Journal:  Eur J Pharmacol       Date:  1979-06       Impact factor: 4.432

3.  Guanine nucleotides modulate muscarinic receptor binding in the heart.

Authors:  C P Berrie; N J Birdsall; A S Burgen; E C Hulme
Journal:  Biochem Biophys Res Commun       Date:  1979-04-27       Impact factor: 3.575

4.  The character of the muscarinic receptors in different regions of the rat brain.

Authors:  N J Birdsall; E C Hulme; A Burgen
Journal:  Proc R Soc Lond B Biol Sci       Date:  1980-02-13

5.  The binding of antagonists to brain muscarinic receptors.

Authors:  E C Hulme; N J Birdsall; A S Burgen; P Mehta
Journal:  Mol Pharmacol       Date:  1978-09       Impact factor: 4.436

6.  The binding of agonists to brain muscarinic receptors.

Authors:  N J Birdsall; A S Burgen; E C Hulme
Journal:  Mol Pharmacol       Date:  1978-09       Impact factor: 4.436

7.  Agonist-antagonist interactions with rat atrial muscarinic cholinergic receptor sites: differential regulation by guanine nucleotides.

Authors:  J W Wei; P V Sulakhe
Journal:  Eur J Pharmacol       Date:  1979-09-01       Impact factor: 4.432

8.  Pirenzepine distinguishes between different subclasses of muscarinic receptors.

Authors:  R Hammer; C P Berrie; N J Birdsall; A S Burgen; E C Hulme
Journal:  Nature       Date:  1980-01-03       Impact factor: 49.962

9.  Effects of several muscarinic agonists on cardiac performance and the release of noradrenaline from sympathetic nerves of the perfused rabbit heart.

Authors:  J R Fozard; E Muscholl
Journal:  Br J Pharmacol       Date:  1972-08       Impact factor: 8.739
  9 in total
  19 in total

Review 1.  Allosteric drugs acting at muscarinic acetylcholine receptors.

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Journal:  Neurochem Res       Date:  2003-04       Impact factor: 3.996

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Authors:  Klaus Mohr; Christian Tränkle; Evi Kostenis; Elisabetta Barocelli; Marco De Amici; Ulrike Holzgrabe
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

Review 3.  Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits.

Authors:  Briana J Davie; Arthur Christopoulos; Peter J Scammells
Journal:  ACS Chem Neurosci       Date:  2013-05-23       Impact factor: 4.418

4.  Investigating the interaction of McN-A-343 with the M muscarinic receptor using its nitrogen mustard derivative and ACh mustard.

Authors:  K W Figueroa; H Suga; F J Ehlert
Journal:  Br J Pharmacol       Date:  2010-07       Impact factor: 8.739

5.  The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor.

Authors:  L K Choo; F Mitchelson; Y M Vong
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-02       Impact factor: 3.000

6.  Cholinomimetic activities of minaprine.

Authors:  P Worms; J P Kan; R Steinberg; J P Terranova; A Perio; K Biziere
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

7.  Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.

Authors:  Katie Leach; Richard E Loiacono; Christian C Felder; David L McKinzie; Adrian Mogg; David B Shaw; Patrick M Sexton; Arthur Christopoulos
Journal:  Neuropsychopharmacology       Date:  2009-11-25       Impact factor: 7.853

8.  Two types of muscarinic response to acetylcholine in mammalian cortical neurons.

Authors:  D A McCormick; D A Prince
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

9.  Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.

Authors:  K J van Charldorp; A de Jonge; M J Thoolen; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-12       Impact factor: 3.000

10.  Interaction of some muscarinic agonists and antagonists at the prejunctional muscarinic receptor in the rabbit ear artery preparation.

Authors:  L K Choo; F Mitchelson; Y M Vong
Journal:  Br J Pharmacol       Date:  1986-04       Impact factor: 8.739
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