Literature DB >> 618727

Imipramine antagonism of apomorphine-induced hypothermia: a non-dopaminergic interaction.

A J Puech, H Francès, P Simon.   

Abstract

Imipramine antagonized high dose apomorphine-induced hypothermia, and did not modify small dose apomorphine-induced hypothermia. It is suggested that apomorphine-induced hypothermia is the result of two effects. The first, induced by small doses of apomorphine, and antagonized by pimozide and sulpiride, is probably related to dopaminergic receptor stimulation. The second, induced by high doses of apomorphine, and antagonized by imipramine, is probably not related to dopaminergic receptor stimulation.

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Year:  1978        PMID: 618727     DOI: 10.1016/0014-2999(78)90383-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  5 in total

1.  Effects of continuous and acute administration of small doses of apomorphine, alone or in combination with chlorpromazine, on the brain monoamines and free amino acid levels in the rat.

Authors:  H Koyuncuoğlu; S Atamer-Simşek; M Keyer-Uysal
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

2.  The functional role of the noradrenergic neurons in the thermoregulatory circuits in mice.

Authors:  E L Schelkunov; O G Andreeva; K F Korovin; M N Ostroumova
Journal:  J Neural Transm       Date:  1981       Impact factor: 3.575

3.  Antagonism of hypothermia and behavioral response to apomorphine: a simple, rapid and discriminating test for screening antidepressants and neuroleptics.

Authors:  A J Puech; R Chermat; M Poncelet; L Doaré; P Simon
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

4.  Hypothermic effects of N-n-propylnorapomorphine in mice: antagonism by neurotransmitter receptor blockers.

Authors:  R E Wilcox; W H Riffee; R V Smith
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

5.  Evidence for the role of noradrenaline in some effects of quipazine.

Authors:  H Francès; Y Lecrubier; A J Puech; P Simon
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

  5 in total

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