Literature DB >> 6186531

Rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by rat liver cytosolic enzymes.

K N Dileepan, J Kennedy.   

Abstract

It had been noted previously that the activity of mitochondrial dihydroorotate dehydrogenase was lower in crude tissue preparations containing cytosol than in isolated mitochondria. Closer examination reveals that the apparent lower enzyme activity is due to rapid conversion of newly-synthesized orotate to uridine-5-monophosphate by the cytosolic enzymes, orotate phosphoribosyltransferase and orotidylate decarboxylase.

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Year:  1983        PMID： 6186531     DOI： 10.1016/0014-5793(83)80107-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Complete inhibition of dihydro-orotate oxidation and superoxide production by 1,1,1-trifluoro-3-thenoylacetone in rat liver mitochondria.

Authors:  K N Dileepan; J Kennedy
Journal:  Biochem J       Date:  1985-01-01       Impact factor: 3.857

Review 2.  Magnesium Orotate and the Microbiome-Gut-Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders.

Authors:  Cristina Schiopu; Gabriela Ștefănescu; Smaranda Diaconescu; Gheoghe G Bălan; Nicoleta Gimiga; Elena Rusu; Cosmin Alec Moldovan; Bogdan Popa; Elena Tataranu; Andrei Vasile Olteanu; Alexandra Boloș; Cristinel Ștefănescu
Journal:  Nutrients       Date:  2022-04-09       Impact factor: 6.706

3.  β-Alanine and orotate as supplements for cardiac protection.

Authors:  Mark F McCarty; James J DiNicolantonio
Journal:  Open Heart       Date:  2014-08-04
  3 in total

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