| Literature DB >> 61864 |
E RUOSLAHTI, H Pihko, M Becker, O Mäkelä.
Abstract
Nanogram quantities of alpha-fetoprotein (AFP), a tumor associated fetal protein, were found in the serum of normal adult rabbits by radioimmunoassay. This AFP was isolated and shown to be immunologically identical to fetal AFP by immunodiffusion. Immunizations of rabbits with unmodified to desialylated AFP in complete Freund's adjuvant did not cause antibody formation, indicating the existence of tolerance against homologous AFP. The tolerance could be terminated by immunizing with hapten-coupled AFP, which resulted in production of rabbit antibodies reacting with unmodified rabbit AFP.Entities:
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Year: 1975 PMID： 61864 DOI： 10.1002/eji.1830050103
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532