Literature DB >> 6186025

Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.

P S Sunkara, N J Prakash, G D Mayer, A Sjoerdsma.   

Abstract

alpha-Difluoromethyl ornithine and mouse type 1 interferon, when administered simultaneously, were highly toxic to B16 melanoma cells in culture. Oral administration of alpha-difluoromethyl ornithine suppressed B16 melanoma development in mice 85 percent whereas interferon given subcutaneously inhibited tumor growth only 24 percent. Total or near total suppression of tumor growth was observed in mice receiving both treatments.

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Year:  1983        PMID： 6186025     DOI： 10.1126/science.6186025

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  The chemotherapeutic potential of polyamine antimetabolites.

Authors:  A N Kingsnorth
Journal:  Ann R Coll Surg Engl       Date:  1986-03       Impact factor: 1.891

2.  alpha-Difluoromethylornithine inhibits liver metastasis produced by intrasplenic injection of human tumor cells into nude mice.

Authors:  K A Zirvi; K S Dasmahapatra; U Atabek; M A Lyons
Journal:  Clin Exp Metastasis       Date:  1989 Nov-Dec       Impact factor: 5.150

3.  Novel therapy for the treatment of human carcinoid.

Authors:  B M Evers; S C Hurlbut; S K Tyring; C M Townsend; T Uchida; J C Thompson
Journal:  Ann Surg       Date:  1991-05       Impact factor: 12.969

4.  Phase I study of combined alpha interferon, alpha difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy.

Authors:  V Ganju; J H Edmonson; J C Buckner
Journal:  Invest New Drugs       Date:  1994       Impact factor: 3.850

5.  Prevention of metastasis of intraocular melanoma in mice treated with difluoromethylornithine.

Authors:  G Sanborn; J Niederkorn; J Kan-Mitchell; D Albert
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1992       Impact factor: 3.117

6.  Polyamines in clinical disorders.

Authors:  D F Tierney; L J Marton; A D Hacker; N Lowe
Journal:  West J Med       Date:  1985-01

7.  Alterations in human circulating and bone marrow mononuclear cell polyamine levels in hematologic malignancies as a consequence of difluoromethylornithine administration.

Authors:  A M Maddox; E J Freireich; M J Keating; K F Frasier-Scott; M K Haddox
Journal:  Invest New Drugs       Date:  1988-06       Impact factor: 3.850

8.  Role of polyamines in the growth of hormone-responsive experimental breast cancer in vivo.

Authors:  A Manni; B Badger; G Luk; C Wright; R Caplan; H Rockette; M Bartholomew; S R Ahmed
Journal:  Breast Cancer Res Treat       Date:  1988-07       Impact factor: 4.872

9.  Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.

Authors:  M Klouche; H Kirchner; F Hölzel
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

10.  The effect of combination treatment with alpha-difluoromethylornithine and Corynebacterium parvum on B16 melanoma growth and tumoricidal effector cell generation in vivo.

Authors:  T L Bowlin; A L Rosenberger; P S Sunkara
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968
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