Literature DB >> 618538

Lysine transfer RNA2 is the major target for L-ethionine in the rat.

Y Kuchino, O K Sharma, E Borek.   

Abstract

Ethionine, a hepatocarcinogen, ethylates macromolecules in vivo especially tRNA of rat liver. When rats were injected with L-[ethyl-3H]ethionine, the tRNA fraction of the liver was found to be labeled. One tRNA with the highest specific activity was purified and identified as lysine-tRNA2.

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Year:  1978        PMID: 618538     DOI: 10.1021/bi00594a021

Source DB:  PubMed          Journal:  Biochemistry        ISSN: 0006-2960            Impact factor:   3.162


  2 in total

1.  Functionally impaired tRNA from ethionine treated rats as detected in injected Xenopus oocytes.

Authors:  I Ginzburg; P Cornelis; D Giveon; U Z Littauer
Journal:  Nucleic Acids Res       Date:  1979-02       Impact factor: 16.971

Review 2.  Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.

Authors:  J H Alix
Journal:  Microbiol Rev       Date:  1982-09
  2 in total

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