Literature DB >> 6184967

Complications after combination of chemotherapy and radiation for malignant brain tumours.

R Dietz, L Burger, K Schimrigk, K H Merkel.   

Abstract

The combination of chemotherapy and irradiation for the treatment of malignant intracerebral tumours is increasing, and survival times longer than those after monotherapy are reported. The suitability of simultaneous radio-chemotherapy using BCNU-Bleomycin, a regimen in which has been followed 38 patients of this hospital (up to 31 December 1981) is critically discussed. Statistics of 30 patients with treatment ended by 31 December 1980 and case histories of two patients with fatal complications, aspergillosis in the one and necrotizing colitis in the other, are presented. The value of the various agents used for chemotherapy is discussed with respect to the survival rates and observed side effects in all the patients. The use of Bleomycin is questioned.

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Year:  1982        PMID： 6184967     DOI： 10.1007/bf01405842

Source DB:  PubMed          Journal:  Acta Neurochir (Wien)        ISSN： 0001-6268            Impact factor:   2.216


  24 in total

1.  Adjuvant chemotherapy with nitrosourea compounds following surgery plus radiotherapy in glioblastoma multiforme.

Authors:  S Monfardini; C Brambilla; C L Solero; A Vaghi; P Valagussa; G Morello; G Bonadonna
Journal:  Recent Results Cancer Res       Date:  1978

2.  Study of effectiveness of bleomycin in rat brain tumor model intravenously and intracerebrally.

Authors:  T S Vats; R A Morantz; G W Wood; S Tilzer
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

3.  The interaction of radiation and bleomycin in intestinal crypt cells.

Authors:  T L Phillips; G Y Ross; L S Goldstein; A C Begg
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

4.  The interaction of irradiation and BCNU in intestinal crypt cells.

Authors:  L S Goldstein; G Y Ross; T L Phillips
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

5.  Comparison of the CCNU and BCNU modification of the in vitro radiation response in 9L brain tumor cells of rats.

Authors:  D F Deen; M E Williams; K T Wheeler
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

6.  Response of a rat brain tumor to fractionated therapy with low doses of BCNU and irradiation.

Authors:  K T Wheeler; K Kaufman; M Feldstein
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

7.  Vascular lesions following perfusion with bleomycin. Electron-microscopic observations.

Authors:  A Burkhardt; W J Höltje; J O Gebbers
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1976-12-27

8.  Radiation plus adjuvant CCNU (1-[2-chloroethyl]-3-cyclohexyl-1-nitrosourea) vs CCNU, hpydroxyurea and vincristine in the treatment of malignant glioma.

Authors:  M Costanza; M Buechler; J Munzenreider; B Emami; B Mukherji; W Shucart; M Scott; L Nathanson; R Rudders; B Stein; K Post; A Piro
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

9.  Treatment of malignant glioma. A controlled study of chemotherapy and irradiation.

Authors:  W R Shapiro; D F Young
Journal:  Arch Neurol       Date:  1976-07

10.  The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

Authors:  I Y Adamson; D H Bowden
Journal:  Am J Pathol       Date:  1974-11       Impact factor: 4.307
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