Literature DB >> 6183624

Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum.

L Barthó, P Holzer, J Donnerer, F Lembeck.   

Abstract

In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (D-Pro2, D-Trp7.9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.

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Year:  1982        PMID： 6183624     DOI： 10.1016/0304-3940(82)90231-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

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Authors:  S K Sarna
Journal:  Dig Dis Sci       Date:  1991-06       Impact factor: 3.199

2.  New models for the evaluation of opioid effects in the guinea-pig ileum.

Authors:  J Donnerer; F Lembeck
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3.  Studies on effects of the substance P analogues [D-Pro2, D-Trp7,9]-substance P and [D-Arg1, D-Trp7,9, L-Leu11]-substance P not related to their antagonist action.

Authors:  F Lembeck; R Amann; L Barthó
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

4.  Tachykinin receptors mediate atropine-resistant rat duodenal reflex contractions in vivo.

Authors:  S Giuliani; M Tramontana; A Lecci; C A Maggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996 Aug-Sep       Impact factor: 3.000

5.  Tachykinin NK1 and NK2 receptor antagonists and atropine-resistant ascending excitatory reflex to the circular muscle of the guinea-pig ileum.

Authors:  C A Maggi; R Patacchini; L Bartho; P Holzer; P Santicioli
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

6.  Release of dynorphin, somatostatin and substance P from the vascularly perfused small intestine of the guinea-pig during peristalsis.

Authors:  J Donnerer; P Holzer; F Lembeck
Journal:  Br J Pharmacol       Date:  1984-12       Impact factor: 8.739

7.  Synergistic role of muscarinic acetylcholine and tachykinin NK-2 receptors in intestinal peristalsis.

Authors:  P Holzer; C A Maggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-02       Impact factor: 3.000

8.  Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors.

Authors:  L Bartho; P Santicioli; R Patacchini; C A Maggi
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Stimulation and inhibition of gastrointestinal propulsion induced by substance P and substance K in the rat.

Authors:  P Holzer
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

Review 10.  Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility.

Authors:  Nick J Spencer; Hongzhen Hu
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-03-09       Impact factor: 46.802
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