| Literature DB >> 6183260 |
O Yoshie, H Schmidt, E S Reddy, S Weissman, P Lengyel.
Abstract
A recombinant clone (pJY150R1.1) encoding the human major histocompatibility antigen (HLA-B7) was introduced into mouse cells and hamster cells by cotransformation with selectable genes. The exposure to mouse interferon of the cells transformed to HLA-B7+ resulted in a severalfold increase in the level of HLA antigen and RNA. The HLA-B7 clone used for the transfection includes a 670-base pair DNA sequence upstream from the coding segment. It remains to be established if the 670-base pair segment is necessary and/or sufficient to make the transcription of the HLA gene responsive to interferon.Entities:
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Year: 1982 PMID: 6183260
Source DB: PubMed Journal: J Biol Chem ISSN: 0021-9258 Impact factor: 5.157