Literature DB >> 6182949

Regulation of substance P by nerve growth factor: disruption by capsaicin.

M S Miller, S H Buck, I G Sipes, H I Yamamura, T F Burks.   

Abstract

Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF). Doses of capsaicin which depleted substance P also inhibited the retrograde axoplasmic transport of NGF. Inhibition of the retrograde transport of NGF by capsaicin preceded substance P depletion. Supplementation of guinea pigs with mouse NGF completely prevented capsaicin-induced substance P depletion. It is concluded that capsaicin depletes substance P from primary afferent neurons of the adult guinea pig by altering the availability of NGF. The data support a role for NGF in the normal maintenance of neuropeptide levels in some sensory neurons in the adult animal.

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Year:  1982        PMID： 6182949     DOI： 10.1016/0006-8993(82)90969-6

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  Cholecystokinin-8 enhances nerve growth factor synthesis and promotes recovery of capsaicin-induced sensory deficit.

Authors:  L Manni; T Lundeberg; P Tirassa; L Aloe
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

2.  Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma).

Authors:  M Matucci-Cerinic; R Giacomelli; A Pignone; M L Cagnoni; S Generini; R Casale; P Cipriani; A Del Rosso; P Tirassa; Y T Konttinen; B M Kahaleh; P S Fan; M Paoletti; C Marchesi; M Cagnoni; L Aloe
Journal:  Ann Rheum Dis       Date:  2001-05       Impact factor: 19.103

3.  Increased circulating nerve growth factor is directly correlated with disease activity in juvenile chronic arthritis.

Authors:  F Falcini; M Matucci Cerinic; A Lombardi; S Generini; A Pignone; P Tirassa; M Ermini; L Lepore; G Partsch; L Aloe
Journal:  Ann Rheum Dis       Date:  1996-10       Impact factor: 19.103

4.  Effects of nerve growth factor on axonal retrograde transport after axonal injury of motoneurons.

Authors:  H Fang; Y Luo
Journal:  J Tongji Med Univ       Date:  1996

5.  Vanilloid receptors in the urinary bladder: regional distribution, localization on sensory nerves, and species-related differences.

Authors:  A Szallasi; B Conte; C Goso; P M Blumberg; S Manzini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-06       Impact factor: 3.000

6.  Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor.

Authors:  D C Taylor; F K Pierau; J Szolcsányi
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

7.  [3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents.

Authors:  A Szallasi; P M Blumberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

8.  Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation.

Authors:  M C Mione; J F Cavanagh; K A Kirkpatrick; G Burnstock
Journal:  Cell Tissue Res       Date:  1992-06       Impact factor: 5.249

9.  Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.

Authors:  M Goedert; U Otten; S P Hunt; A Bond; D Chapman; M Schlumpf; W Lichtensteiger
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

10.  A study of the mode and site of action of capsaicin in guinea-pig heart and rat uterus.

Authors:  G Zernig; P Holzer; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-05       Impact factor: 3.000
  10 in total

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