| Literature DB >> 6182253 |
T Yilma, T C McGuire, L E Perryman.
Abstract
Equine dermal cells induced with poly I:C + DEAE-dextran produced low levels of interferon tentatively classified as equine interferon beta (EqIFN-beta). In contrast, dermal cells initially primed with EqIFN-beta and then superinduced with poly I:C + DEAE-dextran in the presence of cycloheximide and actinomycin D produced greater than 100-fold EqIFN-beta. Equine blood mononuclear cells induced with Newcastle disease virus and phytohemagglutinin produced high levels of interferons tentatively classified as equine interferon alpha (EqIFN-alpha) and equine interferon gamma (EqIFN-gamma), respectively. Both EqIFN-beta and EqIFN-gamma exhibited equivalent antiviral activity on equine, bovine, and ovine cells while EqIFN-alpha had greater activity on bovine and ovine cells than on equine cells. Furthermore, EqIFN-alpha had high antiviral activity on human cells. No detectable levels of antiviral activity of equine interferons was observed on feline and mouse cells.Entities:
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Year: 1982 PMID： 6182253 DOI： 10.1089/jir.1982.2.363
Source DB: PubMed Journal: J Interferon Res ISSN： 0197-8357