Literature DB >> 6182004

Role of urinary alpha1-antitrypsin in Padutin (kallikrein) inactivation.

W H Hörl, R M Schäfer, A Heidland.   

Abstract

An inverse relationship between proteolytic activity in the presence of kallikrein 0.4 IU and urinary alpha1-antitrypsin concentration has been demonstrated. This protease inhibitor can directly inactivate kallikrein activity. The inhibition was abolished by removal of urinary alpha1-antitrypsin by trypsin-sepharose treatment. Inhibition could be reversed by addition of purified alpha1-antitrypsin. These effects could not be demonstrated with inter-alpha-trypsin inhibitor or alpha2-macroglobulin. The inhibitory effect of alpha1-antitrypsin on kallikrein activity should be taken into account in studies in which kallikrein activity is estimated.

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Year:  1982        PMID： 6182004     DOI： 10.1007/bf00609628

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  15 in total

1.  A kallikrein-specific inhibitor in rat kidney tubules.

Authors:  R Geiger; K Mann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1976-04

2.  Purification and some properties of an alkaline proteinase from rat skeletal muscle.

Authors:  B Dahlmann; H Reinauer
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

3.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

4.  Altered urinary kallikrein excretion in rats with hypertension.

Authors:  H S Margolius; R Geller; W De Jong; J J Pisano; A Sjoerdsma
Journal:  Circ Res       Date:  1972-03       Impact factor: 17.367

5.  Plasma bradykinin levels and urinary kallikrein excretion in normal renin essential hypertension.

Authors:  J H Mersey; G H Williams; R Emanuel; R G Dluhy; P Y Wong; T J Moore
Journal:  J Clin Endocrinol Metab       Date:  1979-04       Impact factor: 5.958

6.  Antibody that recognizes total human urinary kallikrein: radioimmunological determination of inactive kallikrein.

Authors:  N B Oza; W Lieberthal; D B Bernard; N G Levinsky
Journal:  J Immunol       Date:  1981-06       Impact factor: 5.422

7.  Alpha 1-antitrypsin and alpha 2-macroglobulin do not inhibit the kinin-releasing activity of kallikreins from human urine and saliva.

Authors:  W Sakamoto; O Nishikaze
Journal:  Biochim Biophys Acta       Date:  1980-12-15

8.  Urinary kallikrein activity in the hypertension of renal parenchymal disease.

Authors:  J A Mitas; S B Levy; R Holle; R P Frigon; R A Stone
Journal:  N Engl J Med       Date:  1978-07-27       Impact factor: 91.245

9.  Absence of binding of pancreatic and urinary kallikreins to alpha 2-macroglobulin.

Authors:  E Vahtera; U Hamberg
Journal:  Biochem J       Date:  1976-08-01       Impact factor: 3.857

10.  Human plasma alpha 2-macroglobulin. An inhibitor of plasma kallikrein.

Authors:  P C Harpel
Journal:  J Exp Med       Date:  1970-08-01       Impact factor: 14.307
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  1 in total

1.  Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation.

Authors:  Thomas Griesbacher; Irmgard Rainer; Beate Tiran; Edwin Fink; Fred Lembeck; Bernhard A Peskar
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739
  1 in total

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