Literature DB >> 6181733

Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties.

R E Brown, F A Stancato, A D Wolfe.   

Abstract

We determined the influence of the azacycloheptane derivative (H) of a 2-acetylpyridine thiosemicarbazone on growth and macromolecular synthesis in Escherichia coli AT-9. Thiosemicarbazone H caused bacteriostasis and a primary inhibition of ribonucleic acid synthesis; secondary effects included inhibition of deoxyribonucleic acid and protein synthesis. Addition of cooper or other transition elements was not necessary for these inhibitions.

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Year:  1981        PMID： 6181733      PMCID： PMC181400          DOI： 10.1128/AAC.19.2.234

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Separation of the inner (cytoplasmic) and outer membranes of Gram-negative bacteria.

Authors:  M J Osborn; R Munson
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

2.  Inactivation of Rous sarcoma virus on contact with N-ethyl isatin -thiosemicarbazone.

Authors:  W Levinson; B Woodson; J Jackson
Journal:  Nat New Biol       Date:  1971-07-28

3.  Are all nucleotidyl transferases metalloenzymes?

Authors:  P Valenzuela; R W Morris; A Faras; W Levinson; W J Rutter
Journal:  Biochem Biophys Res Commun       Date:  1973-08-06       Impact factor: 3.575

4.  Isolation of an E. coli strain with a mutation affecting DNA polymerase.

Authors:  P De Lucia; J Cairns
Journal:  Nature       Date:  1969-12-20       Impact factor: 49.962

5.  Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones.

Authors:  A S Dobek; D L Klayman; E T Dickson; J P Scovill; E C Tramont
Journal:  Antimicrob Agents Chemother       Date:  1980-07       Impact factor: 5.191

6.  Zinc in DNA polymerases.

Authors:  J P Slater; A S Mildvan; L A Loeb
Journal:  Biochem Biophys Res Commun       Date:  1971-07-02       Impact factor: 3.575

7.  The presence and possible role of zinc in RNA polymerase obtained from Escherichia coli.

Authors:  M C Scrutton; C W Wu; D A Goldthwait
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205

8.  RNA-linked nascent DNA fragments in Escherichia coli.

Authors:  A Sugino; S Hirose; R Okazaki
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

9.  Inhibition of RNA-dependent DNA polymerase of Rous sarcoma virus by thiosemicarbazones and several cations.

Authors:  W Levinson; A Faras; B Woodson; J Jackson; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1973-01       Impact factor: 11.205

10.  Reverse transcriptase: correlation of zinc content with activity.

Authors:  B J Poiesz; G Seal; L A Loeb
Journal:  Proc Natl Acad Sci U S A       Date:  1974-12       Impact factor: 11.205
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