Literature DB >> 6181724

The tuberculin specificity in humans of Mycobacterium tuberculosis antigen 5.

T M Daniel, E A Balestrino, O C Balestrino, P T Davidson, S M Debanne, S Kataria, Y P Kataria, J B Scocozza.   

Abstract

Mycobacterium tuberculosis antigen 5 is a protein antigen limited in distribution to M. tuberculosis and M. bovis and capable of eliciting typical delayed tuberculin skin test reactions in humans. A single large batch of this antigen was purified by immunoabsorbent affinity chromatography and used to skin test patients with tuberculosis and other mycobacterial infections and healthy persons in general populations in geographic areas where nonspecific tuberculin reactivity is frequently encountered. Antigen 5 was found to be no more specific as a tuberculin antigen than PPD. If the available data are accepted, then either a disparity in antigen recognition by antibody and T lymphocytes may exist or the widely accepted hypothesis attributing nonspecific tuberculin reactivity to antigenic cross reactivity with other mycobacteria may be incorrect.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6181724     DOI： 10.1164/arrd.1982.126.4.600

Source DB:  PubMed          Journal:  Am Rev Respir Dis        ISSN： 0003-0805


  8 in total

1.  Evaluation of the recombinant 38-kilodalton antigen of Mycobacterium tuberculosis as a potential immunodiagnostic reagent.

Authors:  R J Wilkinson; K Hasløv; R Rappuoli; F Giovannoni; P R Narayanan; C R Desai; H M Vordermeier; J Paulsen; G Pasvol; J Ivanyi; M Singh
Journal:  J Clin Microbiol       Date:  1997-03       Impact factor: 5.948

2.  Immunological activity of a 38-kilodalton protein purified from Mycobacterium tuberculosis.

Authors:  D Young; L Kent; A Rees; J Lamb; J Ivanyi
Journal:  Infect Immun       Date:  1986-10       Impact factor: 3.441

3.  Purification, partial characterization, and identification of a skin-reactive protein antigen of Mycobacterium bovis BCG.

Authors:  J De Bruyn; R Bosmans; M Turneer; M Weckx; J Nyabenda; J P Van Vooren; P Falmagne; H G Wiker; M Harboe
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441

4.  Demonstration of a shared epitope among mycobacterial antigens using a monoclonal antibody.

Authors:  T M Daniel; G R Olds
Journal:  Clin Exp Immunol       Date:  1985-05       Impact factor: 4.330

5.  Specificity of Mycobacterium tuberculosis antigen 5 determined with mouse monoclonal antibodies.

Authors:  T M Daniel; N J Gonchoroff; J A Katzmann; G R Olds
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441

6.  Immunological evaluation of a component isolated from Mycobacterium bovis BCG with a monoclonal antibody to M. bovis BCG.

Authors:  P Minden; P J Kelleher; J H Freed; L D Nielsen; P J Brennan; L McPheron; J K McClatchy
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

7.  Mapping of the delayed-type hypersensitivity-inducing epitope of secreted protein MPT64 from Mycobacterium tuberculosis.

Authors:  T Oettinger; A Holm; I M Mtoni; A B Andersen; K Hasløov
Journal:  Infect Immun       Date:  1995-12       Impact factor: 3.441

8.  Characterization of Mycobacterium tuberculosis antigen 5 epitopes by using a panel of 19 monoclonal antibodies.

Authors:  G R Olds; A J Sanson; T M Daniel
Journal:  J Clin Microbiol       Date:  1987-03       Impact factor: 5.948
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.