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Literature DB >> 6181416

Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA.

A H Wang, S Fujii, J H van Boom, G A van der Marel, S A van Boeckel, A Rich.

Abstract

The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.

Entities: Chemical

Mesh：

Substances：
RNA
DNA

Year: 1982 PMID： 6181416 DOI： 10.1038/299601a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

42 in total

1. Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary polypyrimidine DNA d(CTCTTCTTC).

Authors: Y Xiong; M Sundaralingam
Journal: Nucleic Acids Res Date: 2000-05-15 Impact factor: 16.971

2. The solution structure of [d(CGC)r(aaa)d(TTTGCG)](2): hybrid junctions flanked by DNA duplexes.

Authors: S T Hsu; M T Chou; J W Cheng
Journal: Nucleic Acids Res Date: 2000-03-15 Impact factor: 16.971

3. B-form to A-form conversion by a 3'-terminal ribose: crystal structure of the chimera d(CCACTAGTG)r(G).

Authors: M C Wahl; M Sundaralingam
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

4. Template nucleotide moieties required for de novo initiation of RNA synthesis by a recombinant viral RNA-dependent RNA polymerase.

Authors: M J Kim; W Zhong; Z Hong; C C Kao
Journal: J Virol Date: 2000-11 Impact factor: 5.103

10. Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study.

Authors: K K Chacko; K Lindner; W Saenger; P S Miller
Journal: Nucleic Acids Res Date: 1983-05-11 Impact factor: 16.971

Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA.

1. Crystal structure of a DNA.RNA hybrid duplex with a polypurine RNA r(gaagaagag) and a complementary polypyrimidine DNA d(CTCTTCTTC).

2. The solution structure of [d(CGC)r(aaa)d(TTTGCG)](2): hybrid junctions flanked by DNA duplexes.

3. B-form to A-form conversion by a 3'-terminal ribose: crystal structure of the chimera d(CCACTAGTG)r(G).

4. Template nucleotide moieties required for de novo initiation of RNA synthesis by a recombinant viral RNA-dependent RNA polymerase.

5. The solution structure of [d(CGC)r(amamam)d(TTTGCG)]2.

6. Crystal structure of an Okazaki fragment at 2-A resolution.

7. Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo.

8. Unzipping of A-Form DNA-RNA, A-Form DNA-PNA, and B-Form DNA-DNA in the α-Hemolysin Nanopore.

Review 9. Crystallographic studies of chemically modified nucleic acids: a backward glance.

10. Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study.