Literature DB >> 6181209

Brain transmitter precursors and metabolites in diabetic ketoacidosis.

G Curzon, B D Kantamaneni, N Callaghan, P A Sullivan.   

Abstract

Patients studied during recovery from an episode of ketoacidotic diabetes had raised blood glucose, plasma free fatty acid and plasma free tryptophan concentrations. Plasma total tryptophan was decreased. Well controlled diabetics showed normal values. The ketoacidotic patients had increased lumbar CSF tryptophan and 5-hydroxyindoleacetic acid concentrations. Plasma tyrosine and CSF tyrosine and homovanillic acid concentrations were normal in both diabetic groups. The results are discussed in relation to somewhat similar findings in uraemic and hepatic encephalopathy and to changes in rats with streptozotocin diabetes.

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Year:  1982        PMID： 6181209      PMCID： PMC491424          DOI： 10.1136/jnnp.45.6.489

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  28 in total

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Authors:  J E Fischer; R J Baldessarini
Journal:  Prog Liver Dis       Date:  1976

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Authors:  M G Fitzgerald; D J O'Sullivan; J M Malins
Journal:  Br Med J       Date:  1961-01-28

3.  Cerebral transmitter precursors and metabolites in advanced renal disease.

Authors:  P A Sullivan; D Murnaghan; N Callaghan; B D Kantamaneni; G Curzon
Journal:  J Neurol Neurosurg Psychiatry       Date:  1978-07       Impact factor: 10.154

4.  A simple apparatus for ultrafiltration of small volumes: application to the measurement of free and albumin-bound tryptophan in plasma.

Authors:  D L Bloxam; P H Hutson; G Curzon
Journal:  Anal Biochem       Date:  1977-11       Impact factor: 3.365

5.  Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.

Authors:  P A Friedman; A H Kappelman; S Kaufman
Journal:  J Biol Chem       Date:  1972-07-10       Impact factor: 5.157

6.  Cerebral edema with irreversible coma in severe diabetic ketoacidosis.

Authors:  E Young; R F Bradley
Journal:  N Engl J Med       Date:  1967-03-23       Impact factor: 91.245

7.  Increased tryptophan hydroxylase activity may compensate for decreased brain tryptophan levels in streptozotocin-diabetic rats.

Authors:  M E Trulson; R G MacKenzie
Journal:  J Pharmacol Exp Ther       Date:  1980-02       Impact factor: 4.030

8.  The acute effects of oral (--)-tryptophan in human subjects.

Authors:  M H Greenwood; M H Lader; B D Kantameneni; G Curzon
Journal:  Br J Clin Pharmacol       Date:  1975-04       Impact factor: 4.335

9.  Indolic substances in plasma, cerebrospinal fluid, and frontal cortex of human subjects infused with saline or tryptophan.

Authors:  P K Gillman; J R Bartlett; P K Bridges; A Hunt; A J Patel; B D Kantamaneni; G Curzon
Journal:  J Neurochem       Date:  1981-08       Impact factor: 5.372

10.  Effect of dialysis on plasma and CSF tryptophan and CSF 5-hydroxyindoleacetic acid in advanced renal disease.

Authors:  P A Sullivan; D Murnaghan; N Callaghan; B D Kantamaneni; G Curzon
Journal:  J Neurol Neurosurg Psychiatry       Date:  1980-08       Impact factor: 10.154
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  2 in total

1.  The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes.

Authors:  M Salter; C I Pogson
Journal:  Biochem J       Date:  1985-07-15       Impact factor: 3.857

2.  Serotonin (5-HT) and the rat's eye. Some pilot studies.

Authors:  R M Boerrigter; J V Siertsema; I P Kema
Journal:  Doc Ophthalmol       Date:  1992       Impact factor: 2.379
  2 in total

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