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Literature DB >> 6180978

Migration inhibition of lymph node lymphocytes as an in vitro assay for cell-mediated immunity in the draining lymph nodes of parenterally immunized mice.

Abstract

This paper describes a method for in vitro measurement of specific cell-mediated immunity in the mouse. Animals were immunized parenterally with ovalbumin in Freund's incomplete or complete adjuvant, and a direct migration inhibition assay was performed, using lymphoid cells from the draining lymph nodes. Migration inhibition was found to be antigen specific, correlated with systemic delayed-type hypersensitivity measured in vivo by skin testing, and had a high degree of sensitivity for ovalbumin. The migrating cells were identified as lymphocytes. Lymph node lymphocyte migration inhibition provides a reliable in vitro assay for regional CMI in the mouse.

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Year: 1982 PMID： 6180978 PMCID： PMC1555464

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

15 in total

1. Migration inhibition of T lymphocytes from human peripheral blood by specific antigen and lymphokines.

Authors: D Kowalczyk; M Zembala
Journal: Clin Exp Immunol Date: 1978-05 Impact factor: 4.330

2. Particularity of local immunity in the nasopharynx. Parallel study of surface receptors and cell-mediated immune responses in cells derived from palatine or pharyngeal tonsils and blood.

Authors: R Mazuran; S Rabatić; A Sabioncello; D Dekaris
Journal: Allergy Date: 1979-02 Impact factor: 13.146

7. Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.

Authors: A M Mowat; A Ferguson
Journal: Transplantation Date: 1981-09 Impact factor: 4.939

2. Immunological responses to fed protein antigens in mice. IV. Effects of stimulating the reticuloendothelial system on oral tolerance and intestinal immunity to ovalbumin.

Authors: A M Mowat; D M Parrot
Journal: Immunology Date: 1983-12 Impact factor: 7.397

3. Depletion of suppressor T cells by 2'-deoxyguanosine abrogates tolerance in mice fed ovalbumin and permits the induction of intestinal delayed-type hypersensitivity.

Authors: A M Mowat
Journal: Immunology Date: 1986-06 Impact factor: 7.397

3 in total

Migration inhibition of lymph node lymphocytes as an in vitro assay for cell-mediated immunity in the draining lymph nodes of parenterally immunized mice.

1. Migration inhibition of T lymphocytes from human peripheral blood by specific antigen and lymphokines.

2. Particularity of local immunity in the nasopharynx. Parallel study of surface receptors and cell-mediated immune responses in cells derived from palatine or pharyngeal tonsils and blood.

3. Antigen-induced inhibition of cell migration in agar gel, plasma clot, and liquid media.

4. Migration enhancement factor: a new lymphokine.

5. Lymphokines in sensitized rats. I. Migration inhibitory factor(s) from specifically stimulated thymocytes in vitro.

Review 6. Lymphocyte locomotion. The role of chemokinesis and chemotaxis.

7. Hypersensitivity reactions in the small intestine. 6. Pathogenesis of the graft-versus-host reaction in the small intestinal mucosa of the mouse.

8. Hypersensitivity in the small intestinal mucosa. V. Induction of cell-mediated immunity to a dietary antigen.

9. Chemotaxis of rat lymphocytes.

10. The cell-mediated immune response of the pig to orally administered antigen.

1. Establishment of an animal model of ovalbumin sensitised mouse to study protein induced enteropathy.

2. Immunological responses to fed protein antigens in mice. IV. Effects of stimulating the reticuloendothelial system on oral tolerance and intestinal immunity to ovalbumin.

3. Depletion of suppressor T cells by 2'-deoxyguanosine abrogates tolerance in mice fed ovalbumin and permits the induction of intestinal delayed-type hypersensitivity.