Literature DB >> 6180915

Direct evidence for a release of acetylcholine from the myenteric plexus of guinea pig small intestine by substance P.

W M Yau, M L Youther.   

Abstract

Myenteric plexus-longitudinal muscle strips from guinea pig small intestine were labeled with [3H]choline while under continuous field stimulation. Release of newly synthesized [3H]acetylcholine was studied in the presence of substance P afterwards. Substance P evoked release of [3H]acetylcholine in a dose-related fashion. Both tetrodotoxin and [D-Pro2,D-Phe7,D-Trp9]substance P, a synthetic antagonist of substance P, completely blocked this release and provided evidence for a cholinergically mediated mechanism of substance P on enteric neurons.

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Year:  1982        PMID： 6180915     DOI： 10.1016/0014-2999(82)90357-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  28 in total

1.  Differential role of tachykinin NK3 receptors on cholinergic excitatory neurotransmission in the mouse stomach and small intestine.

Authors:  J G De Man; B Y De Winter; H U De Schepper; A G Herman; P A Pelckmans
Journal:  Br J Pharmacol       Date:  2008-09-22       Impact factor: 8.739

2.  Local cardiac effects of substance P: roles of acetylcholine and noradrenaline.

Authors:  H Chiao; R W Caldwell
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

3.  Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.

Authors:  A J Fox; I K Morton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

4.  Neuropeptide Y-, substance P- and VIP-immunoreactive nerves in cat spleen in relation to autonomic vascular and volume control.

Authors:  J M Lundberg; A Anggård; J Pernow; T Hökfelt
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

5.  A comparison of the effects of three substance P antagonists on tachykinin-stimulated [3H]-acetylcholine release in the guinea-pig ileum.

Authors:  R L Featherstone; P Fosbraey; I K Morton
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

6.  Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum.

Authors:  M Tonini; L Onori; C A Rizzi; E Perucca; L Manzo; A Crema
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

7.  Substance P can contract the longitudinal muscle of the guinea-pig small intestine by releasing intracellular calcium.

Authors:  P Holzer; I T Lippe
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739

8.  Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder.

Authors:  D R Bristow; N R Curtis; N Suman-Chauhan; K J Watling; B J Williams
Journal:  Br J Pharmacol       Date:  1987-01       Impact factor: 8.739

9.  Regulation of the substance P-induced contraction via the release of acetylcholine and gamma-aminobutyric acid in the guinea-pig urinary bladder.

Authors:  J Shirakawa; T Nakanishi; K Taniyama; S Kamidono; C Tanaka
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

10.  Substance P provoked gamma-aminobutyric acid release from the myenteric plexus of the guinea-pig small intestine.

Authors:  C Tanaka; K Taniyama
Journal:  J Physiol       Date:  1985-05       Impact factor: 5.182
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