Literature DB >> 6180809

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs.

J P Schwartz, J Pearson, E M Johnson.   

Abstract

Nerve growth factor (NGF) deprivation was produced in adult rats and guinea pigs by immunization against mouse NGF. Exposure of adult animals to anti-NGF had no effect on sensory ganglion neuronal number or size-frequency histograms. However, the substance P content of sensory ganglia, spinal cord and hind paw skin decreased to as great an extent as was seen in animals exposed to anti-NGF in utero. We conclude that NGF has two separate effects on sensory neurons: adult sensory neurons require NGF for normal function whereas developing neurons require NGF for both survival and transmitter expression.

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Year:  1982        PMID： 6180809     DOI： 10.1016/0006-8993(82)90102-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Role of nerve growth factor in ozone-induced neural responses in early postnatal airway development.

Authors:  Dawn D Hunter; Lynnsey A Carrell-Jacks; Tom P Batchelor; Richard D Dey
Journal:  Am J Respir Cell Mol Biol       Date:  2010-11-12       Impact factor: 6.914

2.  Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons.

Authors:  A M Shadiack; Y Sun; R E Zigmond
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

3.  Effects of central or peripheral axotomy on membrane properties of sensory neurones in the petrosal ganglion of the cat.

Authors:  R Gallego; I Ivorra; A Morales
Journal:  J Physiol       Date:  1987-10       Impact factor: 5.182

4.  Antagonism of nerve growth factor-TrkA signaling and the relief of pain.

Authors:  Patrick W Mantyh; Martin Koltzenburg; Lorne M Mendell; Leslie Tive; David L Shelton
Journal:  Anesthesiology       Date:  2011-07       Impact factor: 7.892

5.  Expression of neuropeptides and neuropeptide mRNAs in spinal cord after axotomy in the rat, with special reference to motoneurons and galanin.

Authors:  X Zhang; V M Verge; Z Wiesenfeld-Hallin; F Piehl; T Hökfelt
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

6.  Revisiting the Koebner phenomenon: role of NGF and its receptor system in the pathogenesis of psoriasis.

Authors:  Siba P Raychaudhuri; Wen-Yue Jiang; Smriti K Raychaudhuri
Journal:  Am J Pathol       Date:  2008-03-18       Impact factor: 4.307

7.  Contribution of nerve growth factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery occlusion.

Authors:  Jihong Xing; Jian Lu; Jianhua Li
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-03-13       Impact factor: 4.733

8.  Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

Authors:  J Diamond; M Coughlin; L Macintyre; M Holmes; B Visheau
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

Review 9.  Diabetic neuropathy: mechanisms to management.

Authors:  James L Edwards; Andrea M Vincent; Hsinlin T Cheng; Eva L Feldman
Journal:  Pharmacol Ther       Date:  2008-06-13       Impact factor: 12.310

10.  Nerve growth factor regulates the action potential duration of mature sensory neurons.

Authors:  A Chalazonitis; E R Peterson; S M Crain
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205
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