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Literature DB >> 6180127

Synthesis of human cytomegalovirus-specified RNA and protein in interferon-treated cells at early times after infection.

M F Stinski, D R Thomsen, J E Rodriguez.

Abstract

In human fibroblast cells treated with interferon, cytomegalovirus-specified immediate early RNA was found associated with the polyribosomes at concentrations and size classes similar to the virus RNA found in non-treated cells, Interferon treatment inhibited the translation of the immediate early virus mRNA; the relative rate of virus-specified immediate early protein and antigen synthesis decreased with increasing concentrations of interferon. In addition, the relative amount of virus-specified RNA associated with the polyribosomes at early times after infection was significantly reduced by treatment of the cells with interferon. Inhibition of infectious virus production in interferon-treated cells was primarily due to inhibition of immediate early virus protein synthesis and secondarily to suppression of early virus RNA synthesis. The role of the virus-specified immediate early proteins in regulating subsequent virus gene expression is discussed.

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Year: 1982 PMID： 6180127 DOI： 10.1099/0022-1317-60-2-261

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

12 in total

1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.

Authors: K C Chin; P Cresswell
Journal: Proc Natl Acad Sci U S A Date: 2001-12-18 Impact factor: 11.205

2. Precise localization of genes on large animal virus genomes: use of lambda gt11 and monoclonal antibodies to map the gene for a cytomegalovirus protein family.

Authors: E S Mocarski; L Pereira; N Michael
Journal: Proc Natl Acad Sci U S A Date: 1985-02 Impact factor: 11.205

3. Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection.

Authors: W F Goins; M F Stinski
Journal: Mol Cell Biol Date: 1986-12 Impact factor: 4.272

4. Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity.

Authors: W J O'Brien; E C Coe; J L Taylor
Journal: Antimicrob Agents Chemother Date: 1990-06 Impact factor: 5.191

10. Human cytomegalovirus UL36-38 and US3 immediate-early genes: temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection.

Authors: D J Tenney; A M Colberg-Poley
Journal: J Virol Date: 1991-12 Impact factor: 5.103

Synthesis of human cytomegalovirus-specified RNA and protein in interferon-treated cells at early times after infection.

1. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.

2. Precise localization of genes on large animal virus genomes: use of lambda gt11 and monoclonal antibodies to map the gene for a cytomegalovirus protein family.

3. Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection.

4. Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity.

5. Organization and expression of the immediate early genes of human cytomegalovirus.

6. Promoter-regulatory region of the major immediate early gene of human cytomegalovirus.

7. Structural analysis of the major immediate early gene of human cytomegalovirus.

8. Effect of recombinant human interferon gamma against human cytomegalovirus.

9. Kaposi's sarcoma-associated herpesvirus virions inhibit interferon responses induced by envelope glycoprotein gpK8.1.

10. Human cytomegalovirus UL36-38 and US3 immediate-early genes: temporally regulated expression of nuclear, cytoplasmic, and polysome-associated transcripts during infection.