Literature DB >> 6179503

Interferon action in human fibroblasts: induction of 2', 5'-oligoadenylate synthetase in the absence of detectable protein kinase activity.

S L Holmes, S L Gupta.   

Abstract

In several strains of human fibroblasts, treatment with human alpha- or beta-interferon (IFN) resulted in an induction of 2', 5'-oligoadenylate synthetase but no protein kinase activity. The antiviral and anticellular effects of IFN are elicited in these cells in the absence of detectable IFN-induced protein kinase activity.

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Year:  1982        PMID： 6179503     DOI： 10.1007/BF01314459

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  15 in total

1.  Specific protein phosphorylation in interferon-treated uninfected and virus-infected mouse L929 cells: enhancement by double-stranded RNA.

Authors:  S L Gupta
Journal:  J Virol       Date:  1979-01       Impact factor: 5.103

2.  Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells.

Authors:  G C Sen; H Taira; P Lengyel
Journal:  J Biol Chem       Date:  1978-09-10       Impact factor: 5.157

3.  pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Authors:  I M Kerr; R E Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

4.  Interferon-induced enzymatic activities and their role in the antriviral state.

Authors:  C Baglioni
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

5.  Interferon effects on the growth and division of human fibroblasts.

Authors:  L M Pfeffer; J S Murphy; I Tamm
Journal:  Exp Cell Res       Date:  1979-06       Impact factor: 3.905

6.  Regulation of interferon action in human fibroblasts: transient induction of specific proteins and amplification of the antiviral response by antinomycin D.

Authors:  S L Gupta; B Y Rubin; S L Holmes
Journal:  Virology       Date:  1981-06       Impact factor: 3.616

7.  Synthesis of low molecular weight inhibitor of protein synthesis with enzyme from interferon-treated cells.

Authors:  A G Hovanessian; R E Brown; I M Kerr
Journal:  Nature       Date:  1977-08-11       Impact factor: 49.962

8.  Interferon-mediated antiviral state in human MRC5 cells in the absence of detectable levels of 2-5A synthetase and protein kinase.

Authors:  E Meurs; A G Hovanessian; L Montagnier
Journal:  J Interferon Res       Date:  1981-02

9.  Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase.

Authors:  C E Samuel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

10.  Interferon enhances 2-5A synthetase in embryonal carcinoma cells.

Authors:  J N Wood; A G Hovanessian
Journal:  Nature       Date:  1979-11-01       Impact factor: 49.962
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  4 in total

1.  Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine.

Authors:  R K Tiwari; J Kusari; R Kumar; G C Sen
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

2.  Differential antiviral effects of interferon in three murine cell lines.

Authors:  G C Sen; R E Herz
Journal:  J Virol       Date:  1983-03       Impact factor: 5.103

3.  Inhibition of vesicular stomatitis viral mRNA synthesis by interferons.

Authors:  L S Belkowski; G C Sen
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103

4.  Effect of interferon on Vero cells persistently infected with SSPE virus and lytically infected with measles virus.

Authors:  M Crespi; M N Chiu; B D Schoub; S F Lyons
Journal:  Arch Virol       Date:  1986       Impact factor: 2.574
  4 in total

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