| Literature DB >> 6179017 |
P Keen, A B Tullo, W A Blyth, T J Hill.
Abstract
The substance P content of the cornea of the adult mouse has been determined by radioimmunoassay. Sympathectomy did not reduce corneal substance P levels. However substance P levels were reduced by 42% following surgical denervation and by 80% following neonatal capsaicin treatment, suggesting that corneal substance P is contained in the peripheral terminals of small diameter sensory neurones. In some mice capsaicin treatment reduced corneal sensitivity; it also resulted in marked corneal vascularization. These effects could not be ascribed to the reduction in corneal substance P.Entities:
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Year: 1982 PMID： 6179017 DOI： 10.1016/0304-3940(82)90322-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046