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Literature DB >> 6178386

Rat hybridoma antibodies against canine parvovirus.

Abstract

Hybrid cells have been produced by fusion between rat myeloma cells IR983F and spleen cells from a LOU rat immunized with canine enteritis parvovirus. Four stable cell lines were selected each secreting a monoclonal antibody directed against this virus. By indirect immunofluorescence, the antigenic determinants recognized by these antibodies were found to be present not only in canine parvovirus infected cells but also in cells infected by the related parvoviruses of mink enteritis and feline panleukopenia. Two of the monoclonal antibodies inhibit hemagglutination by the canine virus and neutralize its infectivity. Hybrid cells were transplanted into histocompatible animals, and large amounts of the antibodies were obtained.

Entities: Disease Species

Mesh：

Substances：

Year: 1982 PMID： 6178386 DOI： 10.1007/BF01315059

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

19 in total

1. The isolation of hybrid cell lines producing monoclonal antibodies against the p15(E) protein of ecotropic murine leukemia viruses.

Authors: R C Nowinski; M E Lostrom; M R Tam; M R Stone; W N Burnette
Journal: Virology Date: 1979-02 Impact factor: 3.616

2. Repertoire of antiviral antibodies expressed by somatic cell hybrids.

Authors: W Gerhard; C M Croce; D Lopes; H Koprowski
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

3. Brief communication: Transplantable immunoglobulin-secreting tumors in rats. V. Monoclonal immunoglobulins secreted by 250 ileocecal immunocytomas in LOU-Wsl rats.

Authors: H Bazin; A Beckers; C Deckers; M Moriamé
Journal: J Natl Cancer Inst Date: 1973-10 Impact factor: 13.506

4. Antigenic differences between canine parvovirus and feline panleucopenia virus.

Authors: R L Flower; G E Wilcox; W F Robinson
Journal: Vet Rec Date: 1980-09-13 Impact factor: 2.695

Review 5. Production of monoclonal antibodies: strategy and tactics.

Authors: S F de StGroth; D Scheidegger
Journal: J Immunol Methods Date: 1980 Impact factor: 2.303

6. Characterization of anti-reovirus immunoglobulins secreted by cloned hybridoma cell lines.

Authors: P W Lee; E C Hayes; W K Joklik
Journal: Virology Date: 1981-01-15 Impact factor: 3.616

7. Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU-Ws1 strain rat immunocytomas and their monoclonal proteins.

Authors: H Bazin; C Deckers; A Beckers; J F Heremans
Journal: Int J Cancer Date: 1972-11 Impact factor: 7.396

2. Structural polypeptides of a canine parvovirus: study by immunoadsorption and sequential analysis of infected cells. Brief report.

Authors: M Surleraux; G Burtonboy
Journal: Arch Virol Date: 1984 Impact factor: 2.574

Rat hybridoma antibodies against canine parvovirus.

1. The isolation of hybrid cell lines producing monoclonal antibodies against the p15(E) protein of ecotropic murine leukemia viruses.

2. Repertoire of antiviral antibodies expressed by somatic cell hybrids.

3. Brief communication: Transplantable immunoglobulin-secreting tumors in rats. V. Monoclonal immunoglobulins secreted by 250 ileocecal immunocytomas in LOU-Wsl rats.

4. Antigenic differences between canine parvovirus and feline panleucopenia virus.

Review 5. Production of monoclonal antibodies: strategy and tactics.

6. Characterization of anti-reovirus immunoglobulins secreted by cloned hybridoma cell lines.

7. Transplantable immunoglobulin-secreting tumours in rats. I. General features of LOU-Ws1 strain rat immunocytomas and their monoclonal proteins.

8. Canine hemorrhagic enteritis: detection of viral particles by electron microscopy.

9. Hemagglutination by canine parvovirus: serologic studies and diagnostic applications.

10. Recovery and characterization of a minute virus of canines.

1. Study of canine parvovirus polypeptides by immunoblot analysis.

2. Structural polypeptides of a canine parvovirus: study by immunoadsorption and sequential analysis of infected cells. Brief report.

3. Monoclonal antibodies directed against different antigenic determinants of rotavirus.

Review 4. Emergence, natural history, and variation of canine, mink, and feline parvoviruses.

Review 5. The application of monoclonal antibodies in the study of viruses.