Literature DB >> 617800

Honey bee venom melittin: correlation of nonspecific inflammatory activities with amino acid sequences.

B F Mackler, G Kreil.   

Abstract

The nonspecific (nonallergic) inflammatory activity of melittin, a protein toxin from honeybees, was correlated with specific amino acid sequences. Two different amino acid sequences of melittin were found to contribute to nonspecific inflammatory activities in guinea pig skin. Carboxy terminal peptide sequences of 7--10 amino acids induced immediate inflammatory reactions that reached maximum intensities by 15--30 min, then rapidly dissipated. The amino (N) terminal hydrophobic sequence, although not directly inflammatory, intensified the immediate reaction, causing a severe lesion evident by 2 h and characterized by massive polymorphonuclear leukocyte infiltration. A conceptual model of bee venom-induced inflammation in nonallergic individuals is suggested.

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Year:  1977        PMID： 617800     DOI： 10.1007/bf00920875

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  15 in total

1.  THE ALLERGIC RESPONSE TO STINGING INSECTS. II. IMMUNOLOGIC STUDIES OF HUMAN SERA FROM ALLERGIC INDIVIDUALS.

Authors:  C LANGLOIS; S SHULMAN; C E ARBESMAN
Journal:  J Allergy       Date:  1965 Jan-Feb

2.  Fluorometric measurements on the interaction of melittin with lecithin.

Authors:  C Mollay; G Kreil
Journal:  Biochim Biophys Acta       Date:  1973-08-23

3.  Allergy to insect stings. I. Diagnosis of IgE-mediated hymenoptera sensitivity by venom-induced histamine release.

Authors:  A K Sobotka; M D Valentine; A W Benton; L M Lichtenstein
Journal:  J Allergy Clin Immunol       Date:  1974-03       Impact factor: 10.793

Review 4.  Allergy to hymenoptera stings--review of the world literature: 1953-1970.

Authors:  S E Barr
Journal:  Ann Allergy       Date:  1971-02

5.  Effects of whole bee venom and its fractions (apamin and melittin) on plasma cortisol levels in the dog.

Authors:  J A Vick; W H Shipman
Journal:  Toxicon       Date:  1972-06       Impact factor: 3.033

6.  Skin test reactivity to the stinging insects.

Authors:  S E Barr
Journal:  Ann Allergy       Date:  1972-05

7.  Hymenoptera sensitivity. Diagnostic and therapeutic studies.

Authors:  A K Sobotka; M D Valentine; A W Benton; N F Adkinson; L M Lichtenstein
Journal:  Int Arch Allergy Appl Immunol       Date:  1975

8.  Allergenic and biological activities of melittin from honey bee venom.

Authors:  B F Mackler; A S Russell; G Kreil
Journal:  Clin Allergy       Date:  1972-12

9.  Action of phospholipases on the cytoplasmic membrane of Escherichia coli. Stimulation by melittin.

Authors:  C Mollay; G Kreil; H Berger
Journal:  Biochim Biophys Acta       Date:  1976-03-05

Review 10.  Procamine and other basic peptides in the venom of the honeybee (Apis mellifera).

Authors:  M L Peck; R O'Connor
Journal:  J Agric Food Chem       Date:  1974 Jan-Feb       Impact factor: 5.279
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  6 in total

1.  Wasp sting of the cornea: a case treated with amniotic membrane transplantation.

Authors:  Zhengri Li; Han-Jin Oh; Yongsok Ji; Kyung Chul Yoon
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2012-06-09       Impact factor: 3.117

Review 2.  Hymenoptera venom allergens.

Authors:  Donald R Hoffman
Journal:  Clin Rev Allergy Immunol       Date:  2006-04       Impact factor: 8.667

3.  Retained bee stinger in the tarsal plate.

Authors:  Sunita Chaurasia; R Muralidhar
Journal:  Int Ophthalmol       Date:  2011-02-01       Impact factor: 2.031

4.  Structure and dynamics of melittin in lysomyristoyl phosphatidylcholine micelles determined by nuclear magnetic resonance.

Authors:  P Yuan; P J Fisher; F G Prendergast; M D Kemple
Journal:  Biophys J       Date:  1996-05       Impact factor: 4.033

5.  Clinical features and management of ocular lesions after stings by hymenopteran insects.

Authors:  K S Siddharthan; Anita Raghavan; R Revathi
Journal:  Indian J Ophthalmol       Date:  2014-02       Impact factor: 1.848

6.  Fatal outcome following multiple bee stings: A rare case.

Authors:  Mahdi Fakhar; Zakaria Zakariaei; Ali Sharifpour; Mostafa Soleymani; Ashkan Zakariaei
Journal:  Clin Case Rep       Date:  2022-01-25
  6 in total

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