Literature DB >> 6177765

Conformational changes in C1q after binding to immune complexes: detection of neoantigens with monoclonal antibodies.

M D Golan, R Burger, M Loos.   

Abstract

The formation of neoantigens within the C1q molecule after the binding of C1r and C1s to C1q and the binding of C1q to immune complexes is described. The neoantigens were detected by different monoclonal anti-C1q antibodies. This immunochemical study supports the hypothesis drawn from functional studies that the activation of the classical C pathway results from conformational changes within the C1q molecule leading to the activation of C1r and subsequently C1s.

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Year:  1982        PMID： 6177765

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  21 in total

Review 1.  Autoantibodies against C1q: view on clinical relevance and pathogenic role.

Authors:  C E Siegert; M D Kazatchkine; A Sjöholm; R Würzner; M Loos; M R Daha
Journal:  Clin Exp Immunol       Date:  1999-04       Impact factor: 4.330

Review 2.  Review: assessment of complement activation in clinical immunology laboratories: time for reappraisal?

Authors:  M Peakman; G Senaldi; D Vergani
Journal:  J Clin Pathol       Date:  1989-10       Impact factor: 3.411

3.  Anti-C1q antibodies in hepatitis C virus infection.

Authors:  D Saadoun; S Sadallah; M Trendelenburg; N Limal; D Sene; J C Piette; J A Schifferli; P Cacoub
Journal:  Clin Exp Immunol       Date:  2006-08       Impact factor: 4.330

4.  Feedback suppression of B cell colony formation in healthy individuals.

Authors:  L A Fernandez; J M Macsween; D A Robson
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

Review 5.  Antibodies against C1q in patients with systemic lupus erythematosus.

Authors:  Marten Trendelenburg
Journal:  Springer Semin Immunopathol       Date:  2005-11-11

6.  A homozygous point mutation results in a stop codon in the C1q B-chain of a C1q-deficient individual.

Authors:  R A McAdam; D Goundis; K B Reid
Journal:  Immunogenetics       Date:  1988       Impact factor: 2.846

Review 7.  Methods to detect and quantitate complement activation.

Authors:  N R Cooper; G R Nemerow; J T Mayes
Journal:  Springer Semin Immunopathol       Date:  1983

8.  [Autoantibodies against the complement component C1q in systemic lupus erythematosus].

Authors:  U Antes; H P Heinz; K Hartung; M Loos
Journal:  Klin Wochenschr       Date:  1990-11-09

9.  Fibronectin binding to complement subcomponent C1q. Localization of their respective binding sites.

Authors:  J Sorvillo; I Gigli; E Pearlstein
Journal:  Biochem J       Date:  1985-02-15       Impact factor: 3.857

10.  IgG autoantibodies to C1q do not detectably influence complement activation in vivo and in vitro in systemic lupus erythematosus.

Authors:  C E Siegert; M R Daha; S Lobatto; E A van der Voort; F C Breedveld
Journal:  Immunol Res       Date:  1992       Impact factor: 2.829
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