Literature DB >> 6177210

Role of histamine in the spasmogenic effect of the complement peptides C3a and C5a-desArg (classical anaphylatoxin).

J Sorgenfrei, B Damerau, W Vogt.   

Abstract

The role of endogenous histamine in the spasmogenic effect of the complement-derived peptides C3a and C5a-desArg (isolated from yeast-activated hog serum) was studied in strips of terminal guinea-pig ileum. The effect of C3a is apparently histamine-independent; it neither induces histamine release from the test organ nor is its spasmogenic action inhibited by the H1-antihistaminics pheniramine and triprolidine, used in concentrations effective against histamine. However, endogenous histamine may be involved in the spasmogenic effect of C5a-desArg; when applied repeatedly C5a-desArg induces histamine release during its first and second application. Furthermore, both H1-antihistaminics inhibited C5a-desArg-induced contractions considerably, though less efficiently than those of added histamine.

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Year:  1982        PMID： 6177210     DOI： 10.1007/BF01965121

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  16 in total

1.  [Histamine-independent effects of anaphylatoxin on smooth muscle of isolated organs].

Authors:  W Vogt; N Zeman; G Garbe
Journal:  Naunyn Schmiedebergs Arch Exp Pathol Pharmakol       Date:  1969

2.  A fragment of the third component of human complement with anaphylatoxin activity.

Authors:  D B Budzko; V A Bokisch; H J Müller-Eberhard
Journal:  Biochemistry       Date:  1971-03-30       Impact factor: 3.162

3.  Release of histamine from rat mast cells by the complement peptides C3a and C5a.

Authors:  A R Johnson; T E Hugli; H J Müller-Eberhard
Journal:  Immunology       Date:  1975-06       Impact factor: 7.397

4.  Contraction of the guinea-pig ileum induced by anaphylatoxin independent of histamine release.

Authors:  G Bodammer; W Vogt
Journal:  Int Arch Allergy Appl Immunol       Date:  1970

5.  Purification and partial characterization of human and porcine C3a anaphylatoxin.

Authors:  T E Hugli; E H Vallota; H J Müller-Eberhard
Journal:  J Biol Chem       Date:  1975-02-25       Impact factor: 5.157

6.  Anaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release.

Authors:  M M Glovsky; T E Hugli; T Ishizaka; L M Lichtenstein; B W Erickson
Journal:  J Clin Invest       Date:  1979-09       Impact factor: 14.808

7.  Purification and partial amino acid sequence of classical anaphylatoxin from pig serum: identification with Des-Arg-C5a.

Authors:  B Zimmermann; B Damerau; W Vogt
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1980

8.  Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: evidence of a modulator role for the oligosaccharide unit in human des-Arg74-C5a.

Authors:  C Gerard; T E Hugli
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

9.  Complement as a mediator of inflammation. 3. Purification of the activity with anaphylatoxin properties generated by interaction of the first four components of complement and its identification as a cleavage product of C'3.

Authors:  W D da Silva; J W Eisele; I H Lepow
Journal:  J Exp Med       Date:  1967-12-01       Impact factor: 14.307

10.  The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement.

Authors:  C G Cochrane; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1968-02-01       Impact factor: 14.307
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  4 in total

1.  Fast deactivation of guinea-pig isolated ileum to C5adesArg: a possible cyclic AMP-dependent mechanism.

Authors:  B Damerau; J Roesler; W Vogt
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

2.  Loss and recovery of sensitivity of guinea-pig isolated ileum to the spasmogenic action of the complement peptide C5adesArg.

Authors:  B Damerau; J Roesler; W Vogt
Journal:  Br J Pharmacol       Date:  1985-01       Impact factor: 8.739

3.  Anaphylatoxin-induced release of histamine from in vitro perfused guinea pig kidney.

Authors:  N A Abdullah; E S Assem; B Damerau
Journal:  Agents Actions       Date:  1988-04

4.  A breakthrough trial of an artificial liver without systemic heparinization in hyperbilirubinemia beagle models.

Authors:  Yilin Wang; Shanshan Wang; Xueqin He; Yupei Li; Tao Xu; Lin Xu; Bo Yang; Xinnian Fan; Weifeng Zhao; Changsheng Zhao
Journal:  Bioact Mater       Date:  2022-07-06
  4 in total

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