Literature DB >> 6177045

HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression.

P Martin, T Papayannopoulou.   

Abstract

A new human erythroleukemia cell line has been established. This line, designated HEL, is capable of spontaneous and induced globin synthesis, producing mainly G gamma and A gamma chains. Embryonic chains (epsilon, zeta) and alpha chains are detectable in very small amounts; beta chains are undetectable. This line provides a new model system for studying aspects of erythroid cell differentiation and differential globin gene expression.

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Year:  1982        PMID： 6177045     DOI： 10.1126/science.6177045

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  147 in total

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3.  Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network.

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4.  The SCL gene is formed from a transcriptionally complex locus.

Authors:  P D Aplan; C G Begley; V Bertness; M Nussmeier; A Ezquerra; J Coligan; I R Kirsch
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

5.  Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.

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6.  Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro.

Authors:  C P Maury; L C Andersson; A M Teppo; S Partanen; E Juvonen
Journal:  Ann Rheum Dis       Date:  1988-12       Impact factor: 19.103

7.  Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.7.

Authors:  F Oakley; N M Horn; A L Thomas
Journal:  J Physiol       Date:  2004-10-14       Impact factor: 5.182

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9.  Differentiation of human erythroid cells is associated with increased O-glycosylation of the major sialoglycoprotein, glycophorin A.

Authors:  C G Gahmberg; M Ekblom; L C Andersson
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10.  VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin.

Authors:  J C van der Loo; X Xiao; D McMillin; K Hashino; I Kato; D A Williams
Journal:  J Clin Invest       Date:  1998-09-01       Impact factor: 14.808
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