Literature DB >> 6176492

Metabolism of 5-fluorouracil in various human normal and tumor tissues.

Y Maehara, S Nagayama, H Okazaki, H Nakamura, T Shirasaka, S Fujii.   

Abstract

The metabolism of 5-fluorouracil (5-FU) in tumors and normal tissues of humans was investigated in vitro. Phosphorylation of 5-FU was faster in tumor tissues than in normal tissues. Phosphorylating activity with 2-deoxy-alpha-D-ribose 1-phosphate (dRiblP) and ATP as cofactors was more active than that with alpha D-ribose 1-phosphate (RiblP) and ATP, or 5-phospho-alpha-D-ribosyldiphosphate (PPRibP) as cofactors. Phosphorylating activity in squamous cell carcinoma of the lung was similar to that in adenocarcinomas. Degradation of 5-FU was much faster in the liver than in other tissues including tumor tissues.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6176492

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  7 in total

1.  The combined antitumour effect of a new 5-fluorouracil derivative, BOF-A2, and radiation in vivo.

Authors:  R Murata; Y Shibamoto; S Miyauchi; M Hirohashi; T Takagi; K Sasai; N Oya; M Hiraoka
Journal:  Br J Cancer Suppl       Date:  1996-07

2.  Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy.

Authors:  L D Stegman; A Rehemtulla; B Beattie; E Kievit; T S Lawrence; R G Blasberg; J G Tjuvajev; B D Ross
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

3.  S-1 in the treatment of advanced and recurrent gastric cancer: current state and future prospects.

Authors:  Ikuo Takahashi; Yoshihiro Kakeji; Yasunori Emi; Masato Sakurai; Yusuke Yonemura; Yasue Kimura; Yoshihiko Maehara
Journal:  Gastric Cancer       Date:  2003       Impact factor: 7.370

4.  5-Fluorouracil's cytotoxicity is enhanced both in vitro and in vivo by concomitant treatment with hyperthermia and dipyridamole.

Authors:  Y Maehara; Y Sakaguchi; I Takahashi; M Yoshida; H Kusumoto; H Masuda; K Sugimachi
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

5.  Effect of gastrectomy on the pharmacokinetics of tegafur, uracil, and 5-fluorouracil after oral administration of a 1:4 tegafur and uracil combination.

Authors:  Y Maehara; H Takeuchi; T Oshiro; I Takahashi; S Inutsuka; H Baba; S Kohnoe; K Sugimachi
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

6.  Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents.

Authors:  S Suga; K Kimura; Y Yokoyama; K Isobe; Y Yoshida; T Takada; A Sato; T Kuwabara; H Iwase
Journal:  Gastroenterol Jpn       Date:  1982

7.  Inhibition of catabolic pathway of 5-fluorouracil by 3-cyano-2,6-dihydroxypyridine in human lung cancer tissues.

Authors:  T Okayasu; K Sugiyama; S Miyauchi
Journal:  Jpn J Cancer Res       Date:  1994-01
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.