Literature DB >> 6176025

Relaxation of isolated gastric smooth muscle cells by vasoactive intestinal peptide.

K N Bitar, G M Makhlouf.   

Abstract

Vasoactive intestinal peptide caused a prompt, dose-dependent relaxation of isolated gastric smooth muscle cells of the guinea pig and a significant increase in intracellular adenosine 3',5'-monophosphate coincidentally with optimum relaxation. Relaxation was augmented by a threshold concentration of isobutyl methylxanthine. The direct relaxant effect of vasoactive intestinal peptide and the distribution of nerves containing this peptide to circular smooth muscle support the view that vasoactive intestinal peptide is the neuromuscular transmitter of enteric inhibitory nerves.

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Year:  1982        PMID： 6176025     DOI： 10.1126/science.6176025

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

2.  Mechanical, electrical and cyclic nucleotide responses to peptide VIP and inhibitory nerve stimulation in rat stomach.

Authors:  S Ito; A Kurokawa; A Ohga; T Ohta; K Sawabe
Journal:  J Physiol       Date:  1990-11       Impact factor: 5.182

3.  Effects of progesterone on motility and prostaglandin levels in the distal guinea pig colon.

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Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-11       Impact factor: 4.052

4.  Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle.

Authors:  Alexander T May; Molly S Crowe; Bryan A Blakeney; Sunila Mahavadi; Hongxia Wang; John R Grider; Karnam S Murthy
Journal:  Peptides       Date:  2018-11-30       Impact factor: 3.750

5.  Simultaneous immunohistochemical demonstration of vasoactive intestinal polypeptide and its receptor in human colon.

Authors:  W Kummer
Journal:  Histochem J       Date:  1990-05

6.  Secretin-induced gastric relaxation is mediated by vasoactive intestinal polypeptide and prostaglandin pathways.

Authors:  Y Lu; C Owyang
Journal:  Neurogastroenterol Motil       Date:  2009-02-23       Impact factor: 3.598

7.  Mediators of nonadrenergic, noncholinergic inhibition in the proximal, middle and distal regions of rat colon.

Authors:  N Suthamnatpong; F Hata; A Kanada; T Takeuchi; O Yagasaki
Journal:  Br J Pharmacol       Date:  1993-02       Impact factor: 8.739

8.  Study of NO and VIP as non-adrenergic non-cholinergic neurotransmitters in the pig gastric fundus.

Authors:  R A Lefebvre; G J Smits; J P Timmermans
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

9.  Functional role of vasoactive intestinal polypeptide in inhibitory motor innervation in the mouse internal anal sphincter.

Authors:  K D Keef; S N Saxton; R A McDowall; R E Kaminski; A M Duffy; C A Cobine
Journal:  J Physiol       Date:  2013-01-21       Impact factor: 5.182

10.  The role of nitric oxide in inhibitory non-adrenergic non-cholinergic neurotransmission in the canine lower oesophageal sphincter.

Authors:  J G De Man; P A Pelckmans; G E Boeckxstaens; H Bult; L Oosterbosch; A G Herman; Y M Van Maercke
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739
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