| Literature DB >> 6175561 |
A Uchida, E M Maida, R Lenzhofer, M Micksche.
Abstract
Peripheral blood lymphocytes from patients with multiple sclerosis (MS) were studied for natural killer (NK) cell activity and reactivity to interferon. NK activity determined at the same time in a 4-hr chromium-51 release assay using K562 target cells was significantly lower in MS patients than in controls. In-vitro treatment of MS lymphocytes with interferon resulted in only a slight increase in NK activity, while NK activity of normal individuals was markedly augmented by interferon. Leukopheresis of MS patients gave a rapid decrease in cytotoxic activity, which returned to pretreatment levels by 24 hrs. These results are consistent with the hypothesis of an immune deficit in multiple sclerosis.Entities:
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Year: 1982 PMID： 6175561 DOI： 10.1016/S0171-2985(82)80003-X
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144