Literature DB >> 6175524

Effect of salbutamol on the cerebral levels, uptake and turnover of serotonin.

S L Erdö, B Kiss, B Rosdy.   

Abstract

The effect of salbutamol (SB) on the cerebral levels of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) was determined as well as the effect on the uptake and turnover of 5-HT in rat brain. SB failed to inhibit the cerebral uptake of 5-HT and did not change 5-HT and 5-HIAA levels in the brain; however, it significantly increased the cerebral turnover of 5-HT. The latter effect may partly be responsible for the antidepressant properties of the compounds.

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Year:  1982        PMID： 6175524     DOI： 10.1016/0014-2999(82)90038-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Effect of beta-adrenoceptor agonists on apomorphine-induced turning in rats.

Authors:  R Ortmann; J G Meisburger; E Mogilnicka
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

2.  Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain.

Authors:  A Bouthillier; P Blier; C de Montigny
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

Review 3.  Salbutamol in the 1980s. A reappraisal of its clinical efficacy.

Authors:  A H Price; S P Clissold
Journal:  Drugs       Date:  1989-07       Impact factor: 9.546

4.  Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1).

Authors:  H Frances; C Bulach; P Simon; M Fillion; G Fillion
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

5.  Effects of inhaled salbutamol in exercising non-asthmatic athletes.

Authors:  C Goubault; M C Perault; E Leleu; S Bouquet; P Legros; B Vandel; A Denjean
Journal:  Thorax       Date:  2001-09       Impact factor: 9.139

6.  Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration.

Authors:  H Francès; R Raisman; P Simon; I Struck
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  6 in total

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