The chemotherapy of advanced squamous cell carcinomas: long term results obtained with a combination of methotrexate, the vinca alkaloids and bleomycin.

Long-term results are described in a group of 119 patients treated by a combination of methotrexate, vinca alkaloids and bleomycin and observed over a period of seven years. Details are given of the chemotherapy used, together with modifications designed to reduce its toxicity. There was an overall objective response in 48% of the patients and this was site dependent with cancer of the head and neck faring best (68%). Overall survival was 8% at two years and was better in patients showing an objective response and also in those whose performance status was improved by treatment. Previous radiotherapy did not appear to affect response adversely. Further studies are proposed with the addition of a cycle specific agent to a modification of the schedule used.