Literature DB >> 6174974

Interactions among iron(II) bleomycin, Lewis bases, and DNA.

W E Antholine, D H Petering, L A Saryan, C E Brown.   

Abstract

The interaction of sulfur-containing ligands with complexes of Fe(II) bleomycin [Fe(II)Blm] was investigated by comparing DNA strand-scission activity with the structural characteristics of the complex. The bithiazole ring of excess Blm can form intermolecular complexes with Fe(II)Blm and with NO-Fe(II)Blm, and the bithiazole groups of CO-Fe(II)Blm interact with the metal center. This binding can be reversed by glutathione, CO-Fe(II)Blm binds to poly(dA-dT) . poly(dA-dT) via its bithiazole group to change the environment of the Fe2+ ion. Glutathione binds to the CO-Fe(II)Blm-poly(dA-dT) . poly(dA-dT) complex under conditions in which it stimulates DNA strand scission by Fe(II)Blm.

Entities:  

Mesh：

Substances：

Year:  1981        PMID： 6174974      PMCID： PMC349299          DOI： 10.1073/pnas.78.12.7517

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Chemical, biochemical, and cellular properties of copper and iron bleomycins.

Authors:  D Solaiman; E A Rao; D H Petering; R C Sealy; W E Antholine
Journal:  Int J Radiat Oncol Biol Phys       Date:  1979-09       Impact factor: 7.038

2.  Reaction of FeBlm with DNA: Fe(II)Blm-NO.

Authors:  W E Antholine; D H Petering
Journal:  Biochem Biophys Res Commun       Date:  1979-11-28       Impact factor: 3.575

Review 3.  Chemistry and mechanism of action of bleomycin.

Authors:  H Umezawa
Journal:  Fed Proc       Date:  1974-11

4.  Bleomycin-A2 complexes with poly(dA--dT): a proton nuclear magnetic resonance study of the nonexchangeable hydrogens.

Authors:  D M Chen; T T Sakai; J D Glickson; D J Patel
Journal:  Biochem Biophys Res Commun       Date:  1980-01-15       Impact factor: 3.575

5.  Properties and products of the degradation of DNA by bleomycin and iron(II).

Authors:  E A Sausville; R W Stein; J Peisach; S B Horwitz
Journal:  Biochemistry       Date:  1978-07-11       Impact factor: 3.162

6.  A role for ferrous ion and oxygen in the degradation of DNA by bleomycin.

Authors:  E A Sausville; J Peisach; S B Horwitz
Journal:  Biochem Biophys Res Commun       Date:  1976-12-06       Impact factor: 3.575

7.  Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex.

Authors:  N J Oppenheimer; L O Rodriguez; S M Hecht
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

8.  Activity and toxicity of bleomycin.

Authors:  M Ishizuka; H Takayama; T Takeuchi; H Umezawa
Journal:  J Antibiot (Tokyo)       Date:  1967-01       Impact factor: 2.649

9.  A 1H nuclear relaxation study of the Mn2+ . bleomycin complex. Proximity of the metal to the DNA-binding site.

Authors:  R P Sheridan; R K Gupta
Journal:  J Biol Chem       Date:  1981-02-10       Impact factor: 5.157

10.  Effect of chelating agents and metal ions on the degradation of DNA by bleomycin.

Authors:  E A Sausville; J Peisach; S B Horwitz
Journal:  Biochemistry       Date:  1978-07-11       Impact factor: 3.162
View more
  3 in total

1.  Thiol-redox antioxidants protect against lung vascular endothelial cytoskeletal alterations caused by pulmonary fibrosis inducer, bleomycin: comparison between classical thiol-protectant, N-acetyl-L-cysteine, and novel thiol antioxidant, N,N'-bis-2-mercaptoethyl isophthalamide.

Authors:  Rishi B Patel; Sainath R Kotha; Lynn A Sauers; Smitha Malireddy; Travis O Gurney; Niladri N Gupta; Terry S Elton; Ulysses J Magalang; Clay B Marsh; Boyd E Haley; Narasimham L Parinandi
Journal:  Toxicol Mech Methods       Date:  2012-06       Impact factor: 2.987

2.  Cross-resistance patterns related to glutathione metabolism in primary human renal cell carcinoma.

Authors:  G Mickisch; S Fajta; H Bier; R Tschada; P Alken
Journal:  Urol Res       Date:  1991

3.  ESR of copper and iron complexes with antitumor and cytotoxic properties.

Authors:  W E Antholine; B Kalyanaraman; D H Petering
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.