Literature DB >> 6174668

T cells cooperating in the induction of delayed-type hypersensitivity act via the linked recognition of antigenic determinants.

M J Tucker, P A Bretscher.   

Abstract

Culture conditions have been established that allow the induction of delayed-type hypersensitivity (DTH) precursor cells present in a cell population derived from unsensitized spleen cells only when antigen-specific, radioresistant, Thy-1-bearing helper cells are added. This specific cellular cooperation acts via the linked recognition of two determinants on the antigen; thus, cells primed to the protein antigen fowl gamma globulin (FGG) will only allow the induction of DTH reactivity against the second antigen, burro erythrocyte (BRBC), when the conjugate FGG-BRBC is present in the cultures. The requirement for physical linkage between the two antigens has been demonstrated by the observation that DTH to BRBC is induced when the conjugate FGG-BRBC is present and not when BRBC and FGG are given an uncoupled molecules.

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Year:  1982        PMID： 6174668      PMCID： PMC2186653          DOI： 10.1084/jem.155.4.1037

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  23 in total

1.  The immune response of normal, irradiated and thymectomized mice to fowl immunoglobulin G as detected by a hemolytic plaque technique.

Authors:  J F Miller; N L Warner
Journal:  Int Arch Allergy Appl Immunol       Date:  1971

2.  Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.

Authors:  A Cohen; M Schlesinger
Journal:  Transplantation       Date:  1970-07       Impact factor: 4.939

3.  Recognition of idiotypes in lymphocyte interactions. I. Idiotypic selectivity in the cooperation between T and B lymphocytes.

Authors:  D Hetzelberger; K Eichmann
Journal:  Eur J Immunol       Date:  1978-12       Impact factor: 5.532

4.  The in vitro induction of T cells which mediate delayed-type hypersensitivity toward horse red blood cells.

Authors:  I A Ramshaw; D Eidinger
Journal:  Cell Immunol       Date:  1979-01       Impact factor: 4.868

5.  T-T interaction in the generation of helper cells in vitro.

Authors:  M Feldmann; D G Kilburn; J Levy
Journal:  Nature       Date:  1975-08-28       Impact factor: 49.962

6.  The mechanism of antigenic stimulation of primary and secondary clonal precursor cells.

Authors:  N R Klinman
Journal:  J Exp Med       Date:  1972-08-01       Impact factor: 14.307

7.  A requirement for antigen-specific helper T cells in the generation of cytotoxic T cells from thymocyte precursors.

Authors:  L M Pilarski
Journal:  J Exp Med       Date:  1977-03-01       Impact factor: 14.307

8.  Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

9.  The requirement of more than one antigenic determinant for immunogenicity.

Authors:  K Rajewsky; V Schirrmacher; S Nase; N K Jerne
Journal:  J Exp Med       Date:  1969-06-01       Impact factor: 14.307

10.  The specificity of allergic reactions. I. Delayed versus Arthus hypersensitivity.

Authors:  S B SALVIN; R F SMITH
Journal:  J Exp Med       Date:  1960-04-01       Impact factor: 14.307
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  17 in total

1.  A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). II. The behavior of the system upon encounter with non-self antigens.

Authors:  Rodney E Langman; James J Mata; Melvin Cohn
Journal:  Int Immunol       Date:  2003-05       Impact factor: 4.823

2.  Th-1 polarization is regulated by dendritic-cell comparison of MHC class I and class II antigens.

Authors:  William K Decker; Dongxia Xing; Sufang Li; Simon N Robinson; Hong Yang; David Steiner; Krishna V Komanduri; Elizabeth J Shpall
Journal:  Blood       Date:  2009-01-26       Impact factor: 22.113

3.  Increasing the foreignness of an antigen, by coupling a second and foreign antigen to it, increases the T helper type 2 component of the immune response to the first antigen.

Authors:  Nahed Ismail; Antony Basten; Helen Briscoe; Peter A Bretscher
Journal:  Immunology       Date:  2005-05       Impact factor: 7.397

4.  Characterization of a cell population which amplifies the anticryptococcal delayed-type hypersensitivity response.

Authors:  P L Fidel; J W Murphy
Journal:  Infect Immun       Date:  1990-02       Impact factor: 3.441

5.  A two-step, two-signal model for the primary activation of precursor helper T cells.

Authors:  P A Bretscher
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

6.  Antigen-specific augmentation factor involved in murine delayed-type footpad reaction. II. Augmentation of delayed-type footpad reaction and acquired resistance to Listeria monocytogenes by transfer of Listeria-immune serum.

Authors:  K Himeno; A Yamada; T Kawakita; S Nakamura; M Mitsuyama; K Nomoto
Journal:  Med Microbiol Immunol       Date:  1987       Impact factor: 3.402

7.  Disruption of Transplant Tolerance by an "Incognito" Form of CD8 T Cell-Dependent Memory.

Authors:  M K Nelsen; K S Beard; R J Plenter; R M Kedl; E T Clambey; R G Gill
Journal:  Am J Transplant       Date:  2017-02-21       Impact factor: 8.086

8.  T helper factor in contact sensitivity: antigen-specific I-A+ helper factor is made by an Lyt-1+2-, I-A+, I-J- T cell.

Authors:  V Colizzi; G L Asherson; B M James; M Malkovsky
Journal:  Immunology       Date:  1984-06       Impact factor: 7.397

9.  Immunogenic cells in the regional lymph nodes after painting with the contact sensitizers picryl chloride and oxazolone: evidence for the presence of IgM antibody on their surface.

Authors:  G L Asherson; V Colizzi; M C Watkins
Journal:  Immunology       Date:  1983-03       Impact factor: 7.397

Review 10.  An alternative to current thinking about positive selection, negative selection and activation of T cells.

Authors:  Melvin Cohn
Journal:  Immunology       Date:  2004-04       Impact factor: 7.397
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