| Literature DB >> 6174209 |
M A Pereira, S L Herren, A L Britt, M M Khoury.
Abstract
The ability of hexachlorobenzene and lindane in diethylnitrosamine (DENA) pretreated rats to enhance the incidence of gamma-glutamyltranspeptidase (GGTase)-positive foci was determined. In rats that received either DENA followed by a basal agar diet or hexachlorobenzene or lindane without prior administration of DENA, the incidence of GGTase-positive foci was negligible. When hexachlorobenzene or lindane were administered in the diet to rats that previously received a 2/3 partial hepatectomy prior to the DENA. The results suggest that hepatocarcinogenicity of hexachlorobenzene and lindane results from tumor promotion.Entities:
Mesh：
Substances：
Year: 1982 PMID： 6174209 DOI： 10.1016/0304-3835(82)90081-7
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679