Literature DB >> 6174176

Depletion of primary afferent substance P by capsaicin and dihydrocapsaicin without altered thermal sensitivity in rats.

S H Buck, M S Miller, T F Burks.   

Abstract

Systemic administration of capsaicin and dihydrocapsaicin to adult rats of two different strains and of capsaicin to neonatal rats, depleted substance P levels in dorsal roots plus ganglia and in dorsal spinal cord. In no case was this depletion accompanied by substantially altered tail-flick latencies. The results are not consistent with a role of the neuropeptide in nociceptive thermal sensitivity in the rat.

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Year:  1982        PMID： 6174176     DOI： 10.1016/0006-8993(82)90945-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  The influence of capsaicin on membrane currents in dorsal root ganglion neurones of guinea-pig and chicken.

Authors:  M Petersen; F K Pierau; M Weyrich
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

Review 2.  Peppers and pain. The promise of capsaicin.

Authors:  B M Fusco; M Giacovazzo
Journal:  Drugs       Date:  1997-06       Impact factor: 9.546

3.  Afferent C-fibres in rats after neonatal capsaicin treatment.

Authors:  E Welk; E Fleischer; U Petsche; H O Handwerker
Journal:  Pflugers Arch       Date:  1984-01       Impact factor: 3.657

4.  Absorption and metabolism of capsaicinoids following intragastric administration in rats.

Authors:  J Donnerer; R Amann; R Schuligoi; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-09       Impact factor: 3.000

5.  Capsaicin in adult frogs: effects on nociceptive responses to cutaneous stimuli and on nervous tissue concentrations of immunoreactive substance P, somatostatin and cholecystokinin.

Authors:  S Chéry-Croze; F Godinot; G Jourdan; C Bernard; J A Chayvialle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

6.  Capsaicin and nociception in the rat and mouse. Possible role of substance P.

Authors:  R Gamse
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-09       Impact factor: 3.000

7.  Species differences in the reflex effects of lingual afferent nerve stimulation on lip blood flow and arterial pressure.

Authors:  S Koeda; M Yasuda; H Izumi
Journal:  J Comp Physiol B       Date:  2003-08-15       Impact factor: 2.200

8.  Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception.

Authors:  J Sawynok; G Robertson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

9.  C-fibre excitation and tonic descending inhibition of dorsal horn neurones in adult rats treated at birth with capsaicin.

Authors:  F Cervero; M B Plenderleith
Journal:  J Physiol       Date:  1985-08       Impact factor: 5.182

Review 10.  Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings.

Authors:  Gyula Mózsik; Tibor Past; Omar M E Abdel Salam; Mónika Kuzma; Pál Perjési
Journal:  Inflammopharmacology       Date:  2009-06-26       Impact factor: 4.473
  10 in total

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