Literature DB >> 6174163

The gamma-delta-beta-globin gene region in G gamma-beta +-hereditary persistence of fetal hemoglobin.

J F Balsley, E Rappaport, E Schwartz, S Surrey.   

Abstract

We report restriction endonuclease analysis of the gamma-delta-beta-globin gene region in a mother and child heterozygous for G gamma-beta +-hereditary persistence of fetal hemoglobin (HPFH). The affected chromosome in these persons directs the production of G gamma-chains and beta-chains but not A gamma-chains. DNA was digested with several restriction enzymes and was examined for gamma, delta, beta sequences by blot hybridization. Only normal digestion fragments were present. By sensitive methods, we were unable to detect a deletion in the entire gamma-delta-beta-globin gene region of the affected chromosome, indicating that in this family, G gamma-beta +-HPFH is not due to a large deletion.

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Year:  1982        PMID： 6174163

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  7 in total

1.  Analysis of 5' flanking regions of the gamma globin genes from major African haplotype backgrounds associated with sickle cell disease.

Authors:  S R Month; R W Wood; P T Trifillis; P J Orchowski; B Sharon; S K Ballas; S Surrey; E Schwartz
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

2.  DNA methylation in hereditary persistence of fetal hemoglobin (HPFH-2).

Authors:  M Poncz; M Sutton; K Delgrosso; E Schwartz; S Surrey
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

3.  G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene.

Authors:  F S Collins; C J Stoeckert; G R Serjeant; B G Forget; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

4.  Restriction endonuclease mapping of gamma-delta-beta-globin region in G gamma (beta)+ HPFH and a Chinese A gamma HPFH variant.

Authors:  M Farquhar; R Gelinas; B Tatsis; J Murray; M Yagi; R Mueller; G Stamatoyannopoulos
Journal:  Am J Hum Genet       Date:  1983-07       Impact factor: 11.025

Review 5.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

6.  A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster.

Authors:  A M Gianni; M Bregni; M D Cappellini; G Fiorelli; R Taramelli; B Giglioni; P Comi; S Ottolenghi
Journal:  EMBO J       Date:  1983       Impact factor: 11.598

7.  A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia.

Authors:  B Giglioni; C Casini; R Mantovani; S Merli; P Comi; S Ottolenghi; G Saglio; C Camaschella; U Mazza
Journal:  EMBO J       Date:  1984-11       Impact factor: 11.598
  7 in total

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