| Literature DB >> 6173747 |
S A Latt, J Allen, S E Bloom, A Carrano, E Falke, D Kram, E Schneider, R Schreck, R Tice, B Whitfield, S Wolff.
Abstract
The effects of a number of chemicals on sister-chromatid exchange (SCE) frequencies in in vivo and in vitro systems are reviewed. Standardized protocols for future SCE testing in important systems, as well as for evaluation of test results, are presented. Data reported thus far suggest that SCE analysis may prove useful, especially at a secondary level, as a test of mutagenic carcinogens. Strengths and limitations of SCE analysis are summarized as a guide for future evaluation and use of this procedure.Entities:
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Year: 1981 PMID： 6173747 DOI： 10.1016/0165-1110(81)90003-8
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433