Literature DB >> 6173230

Resistance of MRL/Mp-lpr/lpr mice to tolerance induction.

T Amagai, B Cinader.   

Abstract

Mice of strain MRL/Mp-lpr/lpr develop resistance against tolerance induction with aggregate-freed rabbit gamma-globulin as early as 6 weeks of age and show very complete resistance when they are 10 weeks old; congenic mice MRL-Mp+/+ of 6 and 10 weeks can be rendered tolerant. By reconstitution experiments, it was shown that T cells from MRL/Mp-lpr/lpr are responsible for the resistance to tolerance induction. A cell which is not colchicine-sensitive contributes to tolerance of MRL/Mp-+/+, but not to MRL/Mp-lpr/lpr mice. Resistance of T cells against tolerance depends on expression of the lpr gene.

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Year:  1981        PMID： 6173230     DOI： 10.1002/eji.1830111113

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  7 in total

1.  Resistant nature of T cells of autoimmune mice to tolerance induction with human serum albumin.

Authors:  M Fujiwara; A Kariyone
Journal:  Immunology       Date:  1982-12       Impact factor: 7.397

Review 2.  Autoimmune diseases: immunopathology and etiopathogenesis.

Authors:  A N Theofilopoulos; F J Dixon
Journal:  Am J Pathol       Date:  1982-09       Impact factor: 4.307

3.  Accelerated development of a Th-2 type factor in animals with and without an imbalance between help and suppression.

Authors:  T Matsuzawa; B Cinader
Journal:  Experientia       Date:  1982-12-15

4.  Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria.

Authors:  J T Venkatraman; R K Tiwari; B Cinader; J Flory; T Wierzbicki; M T Clandinin
Journal:  Lipids       Date:  1991-03       Impact factor: 1.880

5.  One-way occurrence of graft-versus-host disease in bone marrow chimaeras between congenic MRL mice.

Authors:  M Fujiwara; A Kariyone
Journal:  Immunology       Date:  1984-10       Impact factor: 7.397

6.  Studies on the role of the lpr gene in the development of immunological abnormalities and lupus nephritis. Analyses in F2 mice.

Authors:  M Fujiwara; A Kariyone; M Shiraki
Journal:  Clin Exp Immunol       Date:  1985-01       Impact factor: 4.330

Review 7.  Association of lpr gene with graft-vs.-host disease-like syndrome.

Authors:  A N Theofilopoulos; R S Balderas; Y Gozes; M T Aguado; L M Hang; P R Morrow; F J Dixon
Journal:  J Exp Med       Date:  1985-07-01       Impact factor: 14.307
  7 in total

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