Literature DB >> 6173054

Interaction of myelin basic protein with mononuclear cells: the primary reaction for the MEM and EMT tests.

M Goppelt, M Grol, A Pingoud, K Schumacher.   

Abstract

The primary reaction of the macrophage electrophoretic mobility test (MEM) and its modifications (viz. the interaction of myelin basic protein (MBP) and mononuclear cells) has been investigated. The binding of MBP to mononuclear cells is rather weak, and on incubation with mononuclear cells the MBP is proteolytically degraded. A fast process leads to fragments with mol. wts in the range 9000-14,000, followed by a slower process leading to peptides smaller than 5000. Both binding and proteolytic degradation are the same for mononuclear cells from cancer patients and from control individuals.

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Year:  1981        PMID： 6173054      PMCID： PMC2010855          DOI： 10.1038/bjc.1981.282

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  12 in total

1.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

2.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.

Authors:  K Weber; M Osborn
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

3.  Isolation and partial characterization of some proteolytically and chemically derived fragments of bovine encephalitogenic protein.

Authors:  H Bergstrand
Journal:  Eur J Biochem       Date:  1971-07-15

4.  [The EM-test a highly sensitive malignoma test].

Authors:  C Tautz; E Laier; W Schneider
Journal:  Monatsschr Kinderheilkd       Date:  1977-05

5.  Lymphocyte sensitisation: an in-vitro test for cancer?

Authors:  E J Field; E A Caspary
Journal:  Lancet       Date:  1970-12-26       Impact factor: 79.321

6.  Immunological tumour profile: organ-specific carcinoma diagnosis in patients employing the macrophage electrophoretic mobility test.

Authors:  M Müller; J Irmscher; R Fischer; G Heidl; H Grossmann
Journal:  Cancer Lett       Date:  1977-01       Impact factor: 8.679

7.  Immunodiagnostics of malignant diseases. II. The electrophoretic mobility test in the diagnosis of gynecological malignancies.

Authors:  F R Douwes; W Hoffmann; K Mross
Journal:  Oncology       Date:  1977       Impact factor: 2.935

8.  Human peripheral lymphocytes and cancer. In vitro studies on the basic protein, histone F2A1 fraction.

Authors: 
Journal:  Br J Cancer       Date:  1974-09       Impact factor: 7.640

9.  Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies.

Authors:  W Hoffmann; W Werner; R Steiner; R Kaufmann
Journal:  Br J Cancer       Date:  1981-05       Impact factor: 7.640

10.  Effect of lymphocyte supernatants on the electrophoretic mobility of erythrocytes: significance in cancer diagnosis.

Authors:  J E Dyson; P J Corbett
Journal:  Br J Cancer       Date:  1978-09       Impact factor: 7.640
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