Literature DB >> 6172089

Corticolipotropin immunoreactivity in silent chromophobe adenomas: a light and electron microscopic study.

J Hassoun, C Charpin, P Jaquet, J C Lissitzky, F Grisoli, M Toga.   

Abstract

Twenty silent human pituitary adenomas were morphologically studied. Immunoperoxidase methods showed numerous adrenocorticotropic hormone-immunoreactive tumor cells in 14 cases by light microscopy and in one additional case by electron microscopy. Three of these cases were positive for beta-endorphin and one for beta-lipotropin by electron microscopy. These immunoreactions were found in undifferentiated tumors as well as in oncocytic adenomas, and could not be related to the presence of basophils by light microscopy. The peptides so detected in silent adenomas may have no biological activity and may correspond to common precursor molecule subunits.

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Year:  1982        PMID： 6172089

Source DB:  PubMed          Journal:  Arch Pathol Lab Med        ISSN： 0003-9985            Impact factor:   5.534


  8 in total

1.  Silent somatotroph adenomas of the human pituitary. A morphologic study of three cases including immunocytochemistry, electron microscopy, in vitro examination, and in situ hybridization.

Authors:  K Kovacs; R Lloyd; E Horvath; S L Asa; L Stefaneanu; D W Killinger; H S Smyth
Journal:  Am J Pathol       Date:  1989-02       Impact factor: 4.307

2.  Aggressive somatotrophinomas lacking clinical symptoms: neurosurgical management.

Authors:  Mario Giordano; Amir Samii; Rudolf Fahlbusch
Journal:  Neurosurg Rev       Date:  2017-12-30       Impact factor: 3.042

3.  Analysis of endocrine active and clinically silent corticotropic adenomas by in situ hybridization.

Authors:  R V Lloyd; K Fields; L Jin; E Horvath; K Kovacs
Journal:  Am J Pathol       Date:  1990-08       Impact factor: 4.307

4.  Morphological characterization and subtyping of silent somatotroph adenomas.

Authors:  H Naritaka; T Kameya; Y Sato; S Furuhata; M Otani; T Kawase
Journal:  Pituitary       Date:  1999-05       Impact factor: 4.107

5.  Hormone-containing, non-secreting pituitary tumors: clinically silent monohormonal pituitary adenomas.

Authors:  R V Randall; W Scheithauer; E R Laws
Journal:  Trans Am Clin Climatol Assoc       Date:  1985

6.  Immunohistochemical study of pheochromocytomas. An investigation of methionine-enkephalin, vasoactive intestinal peptide, somatostatin, corticotropin, beta-endorphin, and calcitonin in 16 tumors.

Authors:  J Hassoun; G Monges; P Giraud; J F Henry; C Charpin; H Payan; M Toga
Journal:  Am J Pathol       Date:  1984-01       Impact factor: 4.307

7.  In situ hybridization study of pro-opiomelanocortin (POMC) gene expression in human pituitary corticotrophs and their adenomas.

Authors:  L Stefaneanu; K Kovacs; E Horvath; R V Lloyd
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1991

8.  Pituitary adenomas: immunohistology and ultrastructural analysis of 118 tumors.

Authors:  M M Esiri; C B Adams; C Burke; R Underdown
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088
  8 in total

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