Literature DB >> 6171884

Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions.

A S Eison, S D Iversen, B E Sandberg, S P Watson, M R Hanley, L L Iversen.   

Abstract

A metabolically protected analog of substance P, [pGlu5-MePhe8-MeGly9]SP(5-11) (DiMe-C7), was approximately equipotent with substance P in causing increased locomotor activity after microinfusion into the ventral tegmental area of rat brain, but the effects of DiMe-C7 on behavior were considerably prolonged. There was little metabolic degradation of tritiated DiMe-C7 for up to 1 hour after infusion, whereas tritiated substance P was completely degraded within 10 minutes.

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Year:  1982        PMID： 6171884     DOI： 10.1126/science.6171884

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  11 in total

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2.  Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat.

Authors:  A E Kelley; M Cador; L Stinus
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

3.  Effect of substance P on rat gastrointestinal transit.

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4.  Place aversion induced by the substance P analogue, dimethyl-C7, is not state dependent: implication of substance P in aversion.

Authors:  P J Elliott
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

5.  Effect of 5-HT3 receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat.

Authors:  R M Hagan; B J Jones; C C Jordan; M B Tyers
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

Review 6.  Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment.

Authors:  Bankole A Johnson
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

Review 7.  Update on neuropharmacological treatments for alcoholism: scientific basis and clinical findings.

Authors:  Bankole A Johnson
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8.  Rapid degradation of [3H]-substance p in guinea-pig ileum and rat vas deferens in vitro.

Authors:  S P Watson
Journal:  Br J Pharmacol       Date:  1983-06       Impact factor: 8.739

9.  Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.

Authors:  M V Hamity; S R White; D L Hammond
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Review 10.  Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.

Authors:  J P Huston; R U Hasenöhrl; F Boix; P Gerhardt; R K Schwarting
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
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