Literature DB >> 6171034

Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats.

S David, A J Aguayo.   

Abstract

The origin, termination, and length of axonal growth after focal central nervous system injury was examined in adult rats by means of a new experimental model. When peripheral nerve segments were used as "bridges" between the medulla and spinal cord, axons from neurons at both these levels grew approximately 30 millimeters. The regenerative potential of these central neurons seems to be expressed when the central nervous system glial environment is changed to that of the peripheral nervous system.

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Year:  1981        PMID： 6171034     DOI： 10.1126/science.6171034

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  307 in total

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8.  Inactivation of myelin-associated glycoprotein enhances optic nerve regeneration.

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9.  Robust CNS regeneration after complete spinal cord transection using aligned poly-L-lactic acid microfibers.

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10.  Functional Cortical Axon Tracts Generated from Human Stem Cell-Derived Neurons.

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