Literature DB >> 6170901

Immune-type glomerulonephritis induced in the Brown-Norway rat with mercury-containing pharmaceutical products.

P Druet, P Teychenne, C Mandet, C Bascou, E Druet.   

Abstract

It has been shown that Brown-Norway rats develop an immune-type glomerulonephritis after treatment with various mercury-containing drugs. Anti-GBM antibodies were involved, at least in some animals. This glomerulonephritis induced a proteinuria. Strong evidence is given, suggesting that most mercury compounds, some of which, such as mercurial antiseptics, are widely used, could induce an immune-type glomerulonephritis. The question therefore arises, whether these drugs can be used any longer.

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Year:  1981        PMID: 6170901     DOI: 10.1159/000182136

Source DB:  PubMed          Journal:  Nephron        ISSN: 1660-8151            Impact factor:   2.847


  4 in total

Review 1.  Immunologically mediated glomerulonephritis induced by heavy metals.

Authors:  P Druet; A Bernard; F Hirsch; J J Weening; P Gengoux; P Mahieu; S Birkeland
Journal:  Arch Toxicol       Date:  1982-09       Impact factor: 5.153

2.  Immune-mediated glomerulonephritis induced by mercuric chloride in mice.

Authors:  S Eneström; P Hultman
Journal:  Experientia       Date:  1984-11-15

Review 3.  Cytokine regulation of a rodent model of mercuric chloride-induced autoimmunity.

Authors:  L M Bagenstose; P Salgame; M Monestier
Journal:  Environ Health Perspect       Date:  1999-10       Impact factor: 9.031

4.  Mercury-induced renal autoimmunity: changes in RT6+ T-lymphocytes of susceptible and resistant rats.

Authors:  L L Kosuda; D L Greiner; P E Bigazzi
Journal:  Environ Health Perspect       Date:  1993-06       Impact factor: 9.031

  4 in total

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