Literature DB >> 6169540

Preparation and oxygen binding properties of soluble covalent hemoglobin-dextran conjugates.

F Bonneaux, P Labrude, E Dellacherie.   

Abstract

Stroma-free hemoglobin solutions present some drawbacks when used as blood substitutes, essentially because the hemoprotein has a low vascular retention, due to its small hydrodynamic volume. Covalent coupling of the protein with dextran derivatives artificially increases its size and affords polymeric conjugates whose oxygen-binding properties (Barcroft's curve, Hill coefficient) depend on the molecular weight.

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Year:  1981        PMID： 6169540     DOI： 10.1007/BF01985694

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  DETERMINATION OF OXYGEN EQUILIBRIA WITH A VERSATILE NEW TONOMETER.

Authors:  R BENESCH; G MACDUFF; R E BENESCH
Journal:  Anal Biochem       Date:  1965-04       Impact factor: 3.365

2.  Periodate oxidation of carbohydrates.

Authors:  J M BOBBITT
Journal:  Adv Carbohydr Chem       Date:  1956

3.  Soluble dextran-hemoglobin complex as a potential blood substitute.

Authors:  S C Tam; J Blumenstein; J T Wong
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

4.  [Determination of hemoglobin affinity for oxygen].

Authors:  D Labie; V Bycková
Journal:  Nouv Rev Fr Hematol       Date:  1971 Jan-Feb

5.  Evaluation of a stroma-free hemoglobin solution for use as a plasma expander.

Authors:  S F Rabiner; J R Helbert; H Lopas; L H Friedman
Journal:  J Exp Med       Date:  1967-12-01       Impact factor: 14.307
  5 in total
  1 in total

1.  Fixation of various aldehydic dextrans onto human hemoglobin: study of conjugate stability.

Authors:  F Bonneaux; E Dellacherie
Journal:  J Protein Chem       Date:  1995-01
  1 in total

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