Literature DB >> 6169396

Effect of capsaicin administration to neonatal rats on the substance P content of discrete CNS regions.

C J Helke, J A DiMicco, D M Jacobowitz, I J Kopin.   

Abstract

Substance P (SP) levels were determined by radioimmunoassay in microdissected CNS regions of adult animals treated with capsaicin as neonates and of vehicle controls. Capsaicin treatment reduced the SP content of the spinal trigeminal nucleus and the dorsal horn of the spinal cord whereas it had no effect on the SP levels in the ventral horn of the spinal cord, the nucleus tractus solitarius or in midbrain and forebrain areas analyzed.

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Year:  1981        PMID： 6169396     DOI： 10.1016/0006-8993(81)91049-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Professional biographical sketch.

Authors:  David M Jacobowitz
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

Review 2.  Neuropeptide gene expression and neural activity: assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin.

Authors:  G R Uhl; T Nishimori
Journal:  Cell Mol Neurobiol       Date:  1990-03       Impact factor: 5.046

3.  Widespread distribution of substance P- and somatostatin-immunoreactive elements in the spinal cord of the neonatal rat.

Authors:  R H Ho
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249

Review 4.  Regulation of Carcinogenesis by Sensory Neurons and Neuromediators.

Authors:  Nuray Erin; Galina V Shurin; James H Baraldi; Michael R Shurin
Journal:  Cancers (Basel)       Date:  2022-05-09       Impact factor: 6.575

5.  Capsaicin in adult frogs: effects on nociceptive responses to cutaneous stimuli and on nervous tissue concentrations of immunoreactive substance P, somatostatin and cholecystokinin.

Authors:  S Chéry-Croze; F Godinot; G Jourdan; C Bernard; J A Chayvialle
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-11       Impact factor: 3.000

6.  The capsaicin sensitivity of the preoptic region is preserved in adult rats pretreated as neonates, but lost in rats pretreated as adults.

Authors:  M Hajós; F Obál; G Jancsó; F Obál
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-11       Impact factor: 3.000

7.  Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.

Authors:  E Mezey; Z E Tóth; D N Cortright; M K Arzubi; J E Krause; R Elde; A Guo; P M Blumberg; A Szallasi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-28       Impact factor: 11.205
  7 in total

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