Literature DB >> 6169147

Species restriction of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein.

L R Sires, S Hruby, E C Alvord, I Hellström, K E Hellström, M W Kies, R Martemspm, G E Deibler, E D Beckman, J E Casnellie.   

Abstract

A monoclonal antibody (immunoglobulin G1) has been produced that reacts against myelin basic protein present in or extracted from the brains of many mammals-with certain important exceptions. Because of known species differences in amino acid sequences of basic protein and of certain peptide fragments, the binding site for this particular antibody appeared likely to include residues 130 to 137. Confirmation of this hypothesis was obtained by amino acid composition of the major immunoreactive peptides produced by thermolysin digestion of human basic protein and isolated by high-performance liquid chromatography.

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Year:  1981        PMID： 6169147     DOI： 10.1126/science.6169147

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Absence of myelin basic protein in granular cell tumors.

Authors:  P T Osborne; L I Giltman; B R Jennings; G McClellan
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

2.  Ultrastructural immunocytochemistry of glia cells. Double labeling studies using LR White embedding and colloidal gold.

Authors:  M Goto; R Meyermann; H Wekerle
Journal:  Histochemistry       Date:  1987

3.  Proton-n.m.r. study of interaction of myelin basic protein with a monoclonal antibody.

Authors:  G L Mendz; W J Moore; S Easterbrook-Smith; D S Linthicum
Journal:  Biochem J       Date:  1985-05-15       Impact factor: 3.857

4.  Detection of various forms of brain myelin basic protein in vertebrates by electroimmunoblotting.

Authors:  N Kerlero De Rosbo; P R Carnegie; C C Bernard; D S Linthicum
Journal:  Neurochem Res       Date:  1984-10       Impact factor: 3.996

5.  N.m.r. studies of myelin basic protein. Conformation of a peptide that is an antigenic determinant for B-cell reactivity.

Authors:  G L Mendz; W J Moore
Journal:  Biochem J       Date:  1985-07-15       Impact factor: 3.857

6.  Expression of oligodendroglia and Schwann cell markers in human nervous system tumors. An immunomorphological study and western blot analysis.

Authors:  K Schwechheimer; P Gass; H H Berlet
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

Review 7.  Central nervous system myelin: structure, function, and pathology.

Authors:  C M Deber; S J Reynolds
Journal:  Clin Biochem       Date:  1991-04       Impact factor: 3.281
  7 in total

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