Literature DB >> 6168573

Autoantibodies specific to beta-2-microglobulin inhibit the Fc receptor-dependent phagocytosis of human monocytes.

A Falus, M Kávai, K Merétey, S Bozsóky.   

Abstract

Effect of anti-beta2-microglobulin (beta2m) antibodies was investigated on the in vitro Fc and C3 receptor dependent phagocytic capacity of human peripheral monocytes. Both rabbit and human anti-beta2m antibodies inhibit the Fc receptor-mediated phagocytosis. Anti-beta2m antibodies do not influence the spontaneous or C3b receptor-mediated ingestion. The inhibitory activity by human autoantibodies but not by rabbit anti-human beta2m antibodies was diminished when incubation was performed at 37 degrees C instead of 20 degrees C.

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Year:  1981        PMID: 6168573     DOI: 10.1016/0165-2478(81)90094-8

Source DB:  PubMed          Journal:  Immunol Lett        ISSN: 0165-2478            Impact factor:   3.685


  2 in total

Review 1.  Fc receptor--more answers, more questions.

Authors:  L Fornůsek; V Vĕtvicka
Journal:  Folia Microbiol (Praha)       Date:  1984       Impact factor: 2.099

2.  Anticomplement receptor activity in the serum of patients with primary biliary cirrhosis.

Authors:  G Y Minuk; J Vergalla; R G Hanson; J H Hoofnagle; M M Frank; E A Jones
Journal:  Gut       Date:  1986-03       Impact factor: 23.059

  2 in total

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