Literature DB >> 6168488

A negative inotropic effect of acetylcholine in the presence of several phosphodiesterase inhibitors.

H Nawrath, P Gruschwitz, X Zong.   

Abstract

The phosphodiesterase inhibitors papaverine, theophylline and 3-isobutyl-1-methylxanthine (IBMX) reveal a negative inotropic effect of acetylcholine in cat ventricular heart muscle. This effect in unrelated to beta-adrenoceptor stimulation and possibly mediated by the accumulation of cyclic GMP.

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Year:  1981        PMID： 6168488     DOI： 10.1007/BF01967963

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Effects of papaverine and its interaction with isoprenaline and carbachol on the contractile force and cyclic nucleotide levels of the canine ventricular myocardium.

Authors:  M Endoh; M Honma
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000

Review 2.  Cyclic nucleotides and cardiac function.

Authors:  G I Drummond; D L Severson
Journal:  Circ Res       Date:  1979-02       Impact factor: 17.367

3.  Phosphodiesterases from porcine coronary arteries: inhibition of separated forms by xanthines, papaverine, and cyclic nucleotides.

Authors:  J N Wells; Y J Wu; C E Baird; J G Hardman
Journal:  Mol Pharmacol       Date:  1975-11       Impact factor: 4.436

4.  Interaction between cyclic adenosine monophosphate and cyclic gunaosine monophosphate in guinea pig ventricular myocardium.

Authors:  A M Watanabe; H R Besch
Journal:  Circ Res       Date:  1975-09       Impact factor: 17.367

5.  Muscarinic cholinergic receptor modulation of beta-adrenergic receptor affinity for catecholamines.

Authors:  A M Watanabe; M M McConnaughey; R A Strawbridge; J W Fleming; L R Jones; H R Besch
Journal:  J Biol Chem       Date:  1978-07-25       Impact factor: 5.157

6.  Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.

Authors:  H Nawrath
Journal:  Nature       Date:  1976-08-05       Impact factor: 49.962

7.  The inhibitory effect of papaverine on respiration-dependent contracture of giunea pig tainia coli in high-K medium. II. Inhibition of mitochondrial respiration.

Authors:  S Tsuda; N Urakawa; J Fukami
Journal:  Jpn J Pharmacol       Date:  1977-12

Review 8.  The questionable role of cyclic guanosine 3':5'-monophosphate in heart.

Authors:  J Linden; G Brooker
Journal:  Biochem Pharmacol       Date:  1979-12-01       Impact factor: 5.858

9.  Papaverine decreases the efflux of 42K in guinea-pig atrial heart muscle.

Authors:  H Nawrath
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-06       Impact factor: 3.000

10.  Cyclid 3':5'-nucleotide phosphodiesterase. Interconvertible multiple forms and their effects on enzyme activity and kinetics.

Authors:  A L Pichard; W Y Cheung
Journal:  J Biol Chem       Date:  1976-09-25       Impact factor: 5.157
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  4 in total

1.  Chronotropic and inotropic actions of amrinone, carbazeran and isobutylmethyl xanthine: role of phosphodiesterase inhibition.

Authors:  M Shahid; I W Rodger
Journal:  Br J Pharmacol       Date:  1989-09       Impact factor: 8.739

2.  Antimuscarinic action of quinidine on the heart? A study in myocardial preparations from cat hearts.

Authors:  H Nawrath; U Sack; X Zong
Journal:  Br J Pharmacol       Date:  1984-01       Impact factor: 8.739

3.  Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.

Authors:  M Böhm; R Brückner; J Neumann; M Nose; W Schmitz; H Scholz
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

4.  Pronounced cholinergic but only moderate purinergic effects in isolated atrial and ventricular heart muscle from cats.

Authors:  M Kemmer; H Jakob; H Nawrath
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739
  4 in total

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