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Literature DB >> 6168324

Histamine release from human right atrium.

R W Gristwood, J C Lincoln, D A Owen, I R Smith.

Abstract

Histamine release has been detected biologically after exposure of human right atrial biopsy samples to compound 48/80. Human right atrial samples contain large quantities of histamine, 1035 +/- 65 ng/g fresh weight. Exposure of untreated electrically paced atrial strips to compound 84/80, 300 micro/ml, caused an increase in the force of atrial contraction similar to that caused by histamine. Pretreatment of strips with cimetidine, 3.16 x 10(-5) M, prevented the inotropic response to compound 48/80. It is concluded that mast cell degranulation in human atrial tissue can cause sufficient release of histamine to modify the function of the heart.

Entities: Chemical Species

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Year: 1981 PMID： 6168324 PMCID： PMC2071876 DOI： 10.1111/j.1476-5381.1981.tb09947.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

10 in total

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Journal: J Pharmacol Exp Ther Date: 1967-06 Impact factor: 4.030

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Authors: R Levi
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Authors: R W Gristwood; J C Lincoln; D A Owen
Journal: J Pharm Pharmacol Date: 1980-02 Impact factor: 3.765

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Authors: R I Knight; I R Smith; R W Brimblecombe
Journal: Br J Pharmacol Date: 1978-11 Impact factor: 8.739

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Journal: Br J Pharmacol Date: 1979-01 Impact factor: 8.739

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Authors: N Capurro; R Levi
Journal: Br J Pharmacol Date: 1973-08 Impact factor: 8.739

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Authors: M C Petch; W G Nayler
Journal: Br Heart J Date: 1979-03

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Authors: A Giotti; A Guidotti; P F Mannaioni; L Zilletti
Journal: J Physiol Date: 1966-06 Impact factor: 5.182

10 in total

12 in total

Review 1. Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.

Authors: J Llenas; I Cardelús; A Heredia; F de Mora; R W Gristwood
Journal: Drug Saf Date: 1999 Impact factor: 5.606

10. Chronic beta 1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: rôle of cyclic nucleotides.

Authors: L Sanders; J A Lynham; A J Kaumann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1996-05 Impact factor: 3.000

Histamine release from human right atrium.

Review 1. Cardiac histamine receptors.

Review 2. Histamine receptors in the cardiovascular.

3. Drug-induced release and pharmacodynamic effects of histamine in the guinea-pig heart.

4. Effects of exogenous and immunologically released histamine on the isolated heart: a quantitative comparison.

5. Effects of histamine on human isolated heart muscle: comparison with effects of noradrenaline.

6. Separation and quantification of metabolites of radiolabelled histamine in brain [proceedings].

7. Differentiation of the roles of histamine H1- and H2-receptors in the mediation of the effects of histamine in the isolated working heart of the guinea-pig.

8. Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.

9. Concentration of catecholamines in human cardiac muscle.

10. The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro.

Review 1. Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.

2. Effect of picumast on histamine release from rat cardiac and peritoneal mast cells.

3. The effect of compound 48/80, substance P and pentagastrin on the isolated guinea pig atrium.

4. Comparison of the release of various mediators from atrial and ventricular tissues of sensitized guinea-pig hearts.

5. Ventricular histamine concentrations and arrhythmias during acute myocardial ischaemia in rats.

6. Ventricular histamine concentrations and mast cell counts in the rat heart during acute ischaemia.

7. Effects of SK&F 93479 on experimentally induced ventricular arrhythmias in dogs, rats and mice.

8. Effects of ranitidine and cimetidine on experimentally induced ventricular arrhythmias in anaesthetized rats.

9. Ventricular histamine concentrations in naive and morphine-treated rats during acute myocardial ischaemia.

10. Chronic beta 1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: rôle of cyclic nucleotides.